Dornase Alfa


Dornase alfa is used to reduce the number of lung infections and to improve lung function in patients with cystic fibrosis. It breaks down the thick secretions in the airways, allowing air to flow better and preventing bacteria from building up.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Side Effects Of Dornase Alfa

Dornase alfa may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

If you experience either of the following symptoms, call your doctor immediately:

Warnings & Precautions

Before using dornase alfa:

  • tell your doctor and pharmacist if you are allergic to dornase alfa or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using dornase alfa, call your doctor.

Dornase Alfa Dosage

Dornase alfa comes as a solution to inhale by mouth. It usually is taken one or two times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use it exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Dornase alfa is used to treat cystic fibrosis but does not cure it. Continue to use dornase alfa even if you feel well. Do not stop using it without talking to your doctor.

Before you use dornase alfa the first time, read the written instructions that come with it. Ask your doctor, pharmacist, or respiratory therapist to demonstrate the proper technique. Practice using the nebulizer while in his or her presence. Only use a nebulizer that is recommended by your doctor.


Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to it.

Do not dilute or mix dornase alfa with other drugs in the nebulizer.

Inhalation devices require regular cleaning. Follow the manufacturer’s written instructions for the care of the nebulizer.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.