Uses
Linezolid is used to treat infections, including pneumonia, and infections of the skin. Linezolid is in a class of antibacterials called oxazolidinones. It works by stopping the growth of bacteria.
Antibiotics such as linezolid will not work for colds, flu, and other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Side Effects Of Linezolid
Linezolid may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- diarrhea
- headache
- nausea
- vomiting
- stomach pain
- change in the way things taste
- rash
- itching
- dizziness
- white patches in the mouth
- irritation, burning, or itching of the vagina
- change in color of the tongue or teeth
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
- hives, rash, itching, difficulty breathing or swallowing, swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs, hoarseness
- blistering or peeling skin
- repeated nausea and vomiting; fast breathing; confusion; feeling tired
- pain, numbness, or weakness in hands, feet, or other parts of the body
- severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)
- unusual bleeding or bruising
- changes in color vision, blurred vision, or other changes in vision
- seizures
Linezolid may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Warnings & Precautions
Before taking linezolid:
- tell your doctor and pharmacist if you are allergic to linezolid, any other medications, or any of the ingredients in the linezolid product you have been prescribed. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking the following medications or have stopped taking them within the past two weeks: isocarboxazid (Marplan) phenelzine (Nardil). rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Your doctor will probably tell you not to take linezolid if you are taking one or more of these medications, or have taken them within the past two weeks.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: epinephrine (EpiPen); meperidine (Demerol); medications for migraine such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); phenylpropanolamine (no longer available in the US); and pseudoephedrine (Sudafed; in many cold or decongestant medications). Also, tell your doctor if you are taking the following medications or have stopped taking them within the past two weeks: bupropion (Aplenzin, Wellbutrin, Zyban, others); buspirone; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), and vilazodone (Vilbyrd); serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), and venlafaxine (Effexor); and tricyclic antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Also tell your doctor if you are taking fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), or have stopped taking it within the past 5 weeks. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with linezolid, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you have a chronic (long-lasting) infection, or if you have or have ever had carcinoid syndrome (a condition in which a tumor secretes serotonin). diabetes, high blood pressure, hyperthyroidism (an overactive thyroid), immune suppression (problems with your immune system), pheochromocytoma (a tumor of the adrenal gland), seizures, or kidney disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking linezolid, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking linezolid.
- if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent mental retardation), you should know that the oral suspension contains aspartame that forms phenylalanine.
Dosage Of Linezolid
Linezolid comes as a tablet and oral suspension (liquid) to take by mouth. It is usually taken with or without food twice a day (every 12 hours) for 10 to 28 days. Children 11 years of age and younger usually take linezolid with or without food two to three times a day (every 8 to 12 hours) for 10 to 28 days. The length of your treatment depends on the type of infection you have. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take linezolid exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Before using the oral suspension, gently mix it by turning over the bottle three to five times. Do not shake the suspension.
Take linezolid until you finish the prescription, even if you feel better. Do not stop taking linezolid without talking to your doctor. If you stop taking linezolid too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.
Other
Keep all appointments with your doctor and the laboratory. Your doctor may order certain blood tests to check your body’s response to linezolid.
Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the linezolid, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Source
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.
