Panobinostat is used in combination with bortezomib (Velcade) and dexamethasone to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated two other medications, including bortezomib (Velcade). Panobinostat is in a class of medications called histone deacetylase (HDAC) inhibitors. It works by killing cancer cells.

Side Effects Of Panobinostat

Panobinostat may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • weight loss
  • headache

Some side effects can be serious. If you experience any of these symptoms or those listed in the WARNINGS section after taking panobinostat, call your doctor immediately or get emergency medical treatment:

  • black, tarry, or bloody stools
  • bloody vomit or vomited material that looks like coffee grounds
  • unusual bruising or bleeding
  • pink or brown urine
  • blood in phlegm
  • confusion
  • changes in your speech
  • fever, cough, chills, sweating, or other signs of infection
  • pale skin
  • nausea, vomiting, loss of appetite, dark urine, stomach pain, extreme tiredness, lack of energy, or yellowing of skin or white of eyes

Panobinostat may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before taking panobinostat:

  • tell your doctor and pharmacist if you are allergic to panobinostat, any other medications, or any of the ingredients in panobinostat capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone); antifungals such as itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); atomoxetine (Strattera); bepridil (Vascor; no longer available in the U.S.); boceprevir (Victrelis); carbamazepine (Carbatrol, Tegretol, Teril, others); chloroquine (Aralen); clarithromycin (Biaxin, in PrevPac); conivaptan (Vaprisol); desipramine (Norpramin); dextromethorphan; disopyramide (Norpace); dolasetron (Anzemet); certain medications for HIV such as indinavir (Crixivan), lopinavir/ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, in Viekira Pak), saquinavir (Invirase); methadone (Dolophine, Methadose); metoprolol (Lopressor, Toprol-XL); moxifloxacin (Avelox); nebivolol (Bystolic); nefazodone; ondansetron (Zofran, Zuplenz); perphenazine; pimozide (Orap); phenobarbital; phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sotalol (Betapace, Sorine, Sotylize); telaprevir (Incivek; no longer available in U.S.); telithromycin (Ketek); thioridazine; tolterodine (Detrol); and venlafaxine (Effexor). Your doctor may need to change the doses of panobinostat or monitor you carefully for side effects.
  • tell your doctor what herbal products you are taking, especially St John’s wort.
  • tell your doctor if you have an infection or have or have ever had bleeding problems or liver disease.
  • tell your doctor if you are pregnant or plan to become pregnant. Panobinostat may harm the fetus. Use birth control to prevent pregnancy during your treatment with panobinostat and for at least 1 month after the last dose. If you are a man and your partner can become pregnant, you should use a condom while taking this medication and for 90 days after your treatment is completed. Ask your doctor if you have questions about the types of birth control that will work for you. If you become pregnant while taking panobinostat, call your doctor immediately.
  • tell your doctor if you are breastfeeding. You should not breastfeed while taking panobinostat.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking panobinostat.

Panobinostat Dosage

Panobinostat comes as a capsule to take by mouth. It is usually taken with or without food once daily on certain days of a 21-day cycle. The cycle may be repeated for up to 16 cycles. Take panobinostat at around the same time on each scheduled day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take panobinostat exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with a glass of water; do not crush, chew, or open them. Handle the capsules as little as possible. If you touch a broken panobinostat capsule or the medicine in the capsule, wash that area of your body with soap and water. If the medicine in the capsule gets into your mouth, nose, or eyes, wash it away with plenty of water.

If you vomit after taking panobinostat, do not take another dose. Continue your regular dosing schedule.

Be sure to tell your doctor how you are feeling during your treatment. Your doctor may decrease your dose of panobinostat or stop your treatment for a while or permanently if you experience side effects of the medication.


Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription of panobinostat.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information on panobinostat has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.