The combination of pertuzumab, trastuzumab, and hyaluronidase-zzxf is used in combination with chemotherapy to treat certain types of early breast cancer that has spread to nearby tissues. It is also used to treat a certain type of early breast cancer to decrease the chance that a certain type of breast cancer will return. The combination of pertuzumab, trastuzumab, and hyaluronidase-zzxf is also used with docetaxel (Taxotere) to treat certain types of breast cancer that has spread to other parts of the body. Pertuzumab and trastuzumab are in a class of medications called monoclonal antibodies. They work by stopping the growth of cancer cells. Hyaluronidase is an endoglycosidase. It helps to keep pertuzumab and trastuzumab in the body longer so that these medications will have a greater effect.
Side Effects Of Pertuzumab, Trastuzumab, And Hyaluronidase-Zzxf Injection
Pertuzumab, trastuzumab, and hyaluronidase-zzxf may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- hair loss
- dry skin
- stomach pain
- changes in the appearance of nails
- mouth ulcers
- weight loss
- loss of appetite
- changes in taste
- numbness, burning or tingling in the arms, hands, feet, or legs
- arm, leg, back, bone, joint, or muscle pain
- muscle spasms
- pain or redness in the area where pertuzumab, trastuzumab, and hyaluronidase-zzxf was injected
- difficulty falling asleep or staying asleep
- dry eyes or tearing
- hot flashes
Some side effects of pertuzumab, trastuzumab, and hyaluronidase-zzxf injection can be serious. If you experience any of these symptoms or those listed in the WARNINGS and PRECAUTIONS, call your doctor immediately or get emergency medical treatment:
- sore throat, fever, cough, chills, difficult or painful urination, and other signs of infection
- nosebleeds or other unusual bruising or bleeding
- excessive tiredness or pale skin
- rash with blisters on hands and feet
Pertuzumab, trastuzumab, and hyaluronidase-zzxf may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
Warnings & Precautions
Before receiving pertuzumab, trastuzumab, and hyaluronidase-zzxf injection:
- tell your doctor and pharmacist if you are allergic to pertuzumab, trastuzumab, hyaluronidase, any other medications, or any of the ingredients in pertuzumab, trastuzumab, and hyaluronidase injection. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had any of the conditions mentioned in the WARNINGS and PRECAUTIONS section or any other medical condition.
- tell your doctor if you are breast-feeding.
Dosage Of Pertuzumab, Trastuzumab, And Hyaluronidase-Zzxf Injection
Pertuzumab, trastuzumab, and hyaluronidase-zzxf injection come as a liquid to be injected subcutaneously (under the skin). The injection is given by a doctor or nurse in a hospital or medical facility. It is usually given into the thigh over 5 to 8 minutes once every 3 weeks. The length of your treatment will depend on the condition that you have and how well your body responds to treatment.
A doctor or nurse will watch you closely while you are receiving pertuzumab, trastuzumab, and hyaluronidase-zzxf injection and for 15-30 minutes afterward to be sure you are not having a serious reaction to it. Tell your doctor or nurse immediately if you experience any of the following symptoms: fever; chills; nausea; vomiting; diarrhea; rash; hives; itching; swelling of the face, eyes, mouth, throat, tongue, or lips; difficulty breathing or swallowing; or chest pain.
Your doctor may temporarily or permanently stop your treatment. This depends on how well the medication works for you and the side effects you experience. Be sure to tell your doctor how you are feeling during your treatment with pertuzumab, trastuzumab, and hyaluronidase-zzxf injection.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Ask your pharmacist any questions you have about this injection.
Your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with pertuzumab, trastuzumab, and hyaluronidase-zzxf.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.