Trastuzumab and Hyaluronidase-oysk Injection


Trastuzumab and hyaluronidase-oysk injection is used along with other medications or after other medications have already been used to treat a certain type of breast cancer that has spread to other parts of the body. The injection is also used during and after treatment with other medications to decrease the chance that a certain type of breast cancer will return. The injection is in a class of medications called monoclonal antibodies. It works by stopping the growth of cancer cells.

Side Effects Of Trastuzumab and Hyaluronidase-oysk Injection

Trastuzumab and hyaluronidase-oysk injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea
  • constipation
  • stomach pain
  • heartburn
  • loss of appetite
  • changes in taste
  • mouth sores
  • arm, leg, back, bone, joint, or muscle pain
  • pain or redness in the area where the medication was injected
  • hair loss
  • difficulty falling asleep or staying asleep
  • hot flashes
  • numbness, burning or tingling in the arms, hands, feet, or legs
  • changes in the appearance of nails
  • acne
  • depression

Some side effects of trastuzumab and hyaluronidase-oysk injection can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

  • sore throat, fever, chills, difficult or painful urination, and other signs of infection
  • nosebleeds or other unusual bruising or bleeding
  • excessive tiredness
  • pale skin
  • nausea; vomiting; loss of appetite; fatigue; rapid heartbeat; dark urine; decreased amount of urine; stomach pain; seizures; hallucinations; or muscle cramps and spasms

Trastuzumab and hyaluronidase-oysk injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

Warnings & Precautions

Before receiving trastuzumab and hyaluronidase-oysk injection:

  • tell your doctor and pharmacist if you are allergic to trastuzumab, hyaluronidase (Amphadase, Vitrase), any other medications, or any of the ingredients in trastuzumab and hyaluronidase-oysk injection.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the WARNING section, especially if you receive them within 7 months after stopping the injection. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or any other medical condition.
  • tell your doctor if you are breastfeeding.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving trastuzumab and hyaluronidase-oysk injection.

Dosage Of Trastuzumab and Hyaluronidase-oysk Injection

The injection comes as a liquid to be injected under the skin in the thigh over 2 to 5 minutes. Trastuzumab and hyaluronidase-oysk injection is given by a doctor or nurse in a hospital or medical facility. It is usually given once every 3 weeks. The length of your treatment will depend on the condition that you have and how well your body responds to treatment.


Ask your pharmacist any questions you have about the injection.

Your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with trastuzumab and hyaluronidase-oysk injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information on trastuzumab and hyaluronidase-oysk injection has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.