Uses of Pamidronate Injection
Pamidronate injection is used to treat high levels of calcium in the blood that may be caused by certain types of cancer. Pamidronate is also used along with cancer chemotherapy to treat bone damage caused by multiple myeloma (cancer that begins in the plasma cells [a type of white blood cell that produces substances needed to fight infection]) or by breast cancer that has spread to the bones. Pamidronate is also used to treat Paget’s disease (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken).
Pamidronate injection is in a class of medications called bisphosphonates. It works by slowing bone breakdown, increasing bone density (thickness), and decreasing the amount of calcium released from the bones into the blood.
Side Effects of Pamidronate Injection
Pamidronate injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- redness, swelling, or pain in the injection spot
- stomach pain
- loss of appetite
- change in the ability to taste food
- sores in the mouth
- excessive tiredness
- difficulty falling asleep or staying asleep
- difficulty urinating or painful urination
- swelling of the hands, arms, feet, ankles, or lower legs
Some side effects of pamidronate injection can be serious. If you experience any of these symptoms, call your doctor immediately:
- painful or swollen gums
- loosening of the teeth
- numbness or heavy feeling in the jaw
- poor healing of the jaw
- vomit that is bloody or looks like coffee grounds
- bloody or black and tarry stools
- shortness of breath
- fast heartbeat
- a sudden tightening of muscles
- numbness or tingling around the mouth
- eye pain or tearing
Pamidronate injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Warnings & Precautions
Before receiving pamidronate injection:
- tell your doctor and pharmacist if you are allergic to pamidronate injection, alendronate (Fosamax), etidronate (Didronel), risedronate (Actonel), tiludronate (Skelid), zoledronic acid (Zometa), any other medications, or any of the ingredients in pamidronate injection. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take with pamidronate injection. Be sure to mention any of the following: cancer chemotherapy medications; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); and thalidomide (Thalomid). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with pamidronate injection, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you are being treated with radiation therapy and if you have or have ever had thyroid surgery, seizures, or liver or kidney disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should use a reliable method of birth control to prevent pregnancy while you are receiving pamidronate injection. If you become pregnant while receiving pamidronate, call your doctor immediately. Talk to your doctor if you plan to become pregnant at any time in the future because pamidronate may remain in your body for years after you stop using it.
- you should know that pamidronate may cause serious problems with your jaw, especially if you have dental surgery or treatment while you are taking the medication. A dentist should examine your teeth and perform any needed treatments before you start to receive pamidronate. Be sure to brush your teeth and clean your mouth properly while you are receiving pamidronate injection. Talk to your doctor before having any dental treatments while you are receiving this medication.
- you should know that pamidronate injection may cause severe bone, muscle, or joint pain. You may begin to feel this pain within days, months, or years after you first receive pamidronate injection. Although this type of pain may begin after you have received pamidronate injection for some time, it is important for you and your doctor to realize that it may be caused by pamidronate. Call your doctor right away if you experience severe pain at any time during your treatment with pamidronate injection. Your doctor may stop giving you pamidronate injection and your pain may go away after you stop treatment with this medication.
Pamidronate injection comes as a solution (liquid) to inject into a vein slowly, over 2 to 24 hours. It is usually injected by a health care provider in a doctor’s office, hospital, or clinic. It may be given once every 3 to 4 weeks, once a day for 3 days in a row, or as a single dose that may be repeated after 1 week or longer. The treatment schedule depends on your condition.
Your doctor may recommend a calcium supplement and a multivitamin containing vitamin D to take during your treatment. You should take these supplements every day as directed by your doctor.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body’s response to pamidronate injection.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.