Methyldopa and Hydrochlorothiazide, Chlorothiazide

Methyldopa And Hydrochlorothiazide, Chlorothiazide
Methyldopa And Hydrochlorothiazide, Chlorothiazide

Uses of Methyldopa and Hydrochlorothiazide

The combination of methyldopa and hydrochlorothiazide is used to treat high blood pressure. Methyldopa works by relaxing the blood vessels so that blood can flow more easily through the body. Hydrochlorothiazide helps to lower blood pressure by eliminating unneeded water and salt from the body.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Side Effects of Methyldopa and Hydrochlorothiazide

Methyldopa and hydrochlorothiazide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dark urine
  • frequent urination
  • dry mouth
  • headache
  • upset stomach
  • vomiting
  • loss of appetite
  • diarrhea
  • gas
  • rash

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • extreme tiredness
  • muscle weakness or cramps
  • unexplained fever
  • yellowing of the skin or eyes
  • trouble breathing
  • swollen ankles or feet

This medication may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

Warnings & Precautions

Before taking methyldopa and hydrochlorothiazide:

  • tell your doctor and pharmacist if you are allergic to methyldopa, hydrochlorothiazide, sulfa medications, any other medications, or any of the ingredients in methyldopa and hydrochlorothiazide tablets. Ask your doctor or pharmacist for a list of the ingredients.
  • tell your doctor if you are taking a monoamine oxidase (MAOs) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Your doctor will probably tell you not to take methyldopa and hydrochlorthiazide.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cholestyramine (Prevalite), digoxin (Lanoxin), haloperidol (Haldol), levodopa (in Sinemet, in Stalevo), lithium (Lithobid), medications for diabetes, prednisone (Rayos), probenecid (Probalan, in Col-Probenecid), and tolbutamide. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • if you are taking iron supplements or vitamins containing iron, do not take them at the same time as you take methyldopa and hydrochlorthiazide. Ask your doctor how long you should wait after taking these supplements before you take methyldopa.
  • tell your doctor if you have or have ever had kidney or liver disease, diabetes, gout, or high blood cholesterol.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking methyldopa and hydrochlorothiazide, call your doctor.
  • talk to your doctor about the risks and benefits of taking methyldopa and hydrochlorothiazide if you are 65 years of age or older. Older adults should not usually take methyldopa and hydrochlorothiazide because it is not as safe as other medications that can be used to treat the same condition.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking methyldopa and hydrochlorothiazide.
  • you should know that this medication may make you drowsy. Do not drive a car or operate machinery for 48-72 hours after you begin to take this medication or after your dose is increased.
  • ask your doctor about the safe use of alcohol while you are taking methyldopa and hydrochlorothiazide. Alcohol can make the side effects of methyldopa and hydrochlorothiazide worse.


This medication comes as a tablet to take by mouth. It usually is taken two or three times a day. To help you remember to take methyldopa and hydrochlorothiazide, take it around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take methyldopa and hydrochlorothiazide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

This medication controls high blood pressure but does not cure it. Continue to take methyldopa and hydrochlorothiazide even if you feel well. Do not stop taking methyldopa and hydrochlorothiazide without talking to your doctor.


Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to methyldopa and hydrochlorothiazide.

To relieve dry mouth caused by methyldopa and hydrochlorothiazide, chew gum or suck sugarless hard candy.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.