Uses
The combination of lisinopril and hydrochlorothiazide is used to treat high blood pressure. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly. Hydrochlorothiazide is in a class of medications called diuretics (‘water pills’). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.
High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.
Side Effects Of Lisinopril and Hydrochlorothiazide
Lisinopril and hydrochlorothiazide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dizziness
- headache
- cough
- excessive tiredness
- pain, burning, or tingling in the hands or feet
- the decrease in sexual ability
- heartburn
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- hoarseness
- difficulty breathing or swallowing
- stomach pain
- upset stomach
- vomiting
- fever, sore throat, chills, and other signs of infection
- muscle pain, cramps, or weakness
- yellowing of the skin or eyes
- dry mouth
- thirst
- weakness
- restlessness
- confusion
- seizures
- decrease in urination
- lightheadedness
- fainting
- chest pain
- rapid, pounding, slow, or irregular heartbeat
- pain in the big toe
- tingling in arms and legs
- loss of muscle tone
- weakness or heaviness in legs
- lack of energy
- cold, gray skin
Lisinopril and hydrochlorothiazide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Warnings & Precautions
Before taking lisinopril and hydrochlorothiazide:
- tell your doctor and pharmacist if you are allergic to lisinopril; hydrochlorothiazide (HCTZ, Microzide, Oretic); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec, in Vaseretic), fosinopril (Monopril), lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); sulfa drugs; any other medications, or any ingredients in lisinopril and hydrochlorothiazide tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor or pharmacist if you are taking valsartan and sacubitril (Entresto) or if you have stopped taking it within the last 36 hours. Your doctor will probably tell you not to take lisinopril and hydrochlorothiazide, if you are also taking valsartan and sacubitril. Also, tell your doctor if you have diabetes and you are taking aliskiren (Tekturna, in Amturnide, Tekamlo, Tekturna HCT). Your doctor will probably tell you not to take lisinopril and hydrochlorothiazide if you have diabetes and you are also taking aliskiren.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin), indomethacin (Indocin), and naproxen (Aleve, Naprosyn); barbiturates such as phenobarbital (Luminal, ); cholestyramine (Prevalite); colestipol (Colestid); digoxin (Lanoxin); insulin or oral medications for diabetes; lithium (Lithobid); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); other diuretics; other medications for high blood pressure; pain medications; and potassium supplements. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you are on dialysis or are being treated with desensitization (a process to reduce your reaction to an allergen) and if you have or have ever had allergies; asthma; diabetes; gout; high cholesterol; collagen vascular disease such as lupus or scleroderma (a condition in which extra tissue grows on the skin and some organs); heart failure; any condition that causes you to urinate less than you normally do; a stroke or ‘mini-stroke’; heart, kidney, or liver disease; or angioedema (a condition that causes difficulty swallowing or breathing and painful swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs).
- tell your doctor if you are breast-feeding.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lisinopril and hydrochlorothiazide.
- ask your doctor about the safe use of alcoholic beverages while you are taking lisinopril and hydrochlorothiazide. Alcohol can make the side effects from lisinopril and hydrochlorothiazide worse.
- you should know that diarrhea, vomiting, not drinking enough fluids, and sweating a lot can cause a drop in blood pressure, which may cause lightheadedness and fainting.
- you should know that lisinopril and hydrochlorothiazide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking lisinopril and hydrochlorothiazide. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
Lisinopril and Hydrochlorothiazide Dosage
The combination of lisinopril and hydrochlorothiazide comes as a tablet to take by mouth. It is usually taken once a day with or without food. To help you remember to take lisinopril and hydrochlorothiazide, take them around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lisinopril and hydrochlorothiazide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Lisinopril and hydrochlorothiazide controls high blood pressure but does not cure it. Continue to take lisinopril and hydrochlorothiazide even if you feel well. Do not stop taking lisinopril and hydrochlorothiazide without talking to your doctor.
Other
Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to lisinopril and hydrochlorothiazide. Your doctor may order certain lab tests to check your body’s response to lisinopril and hydrochlorothiazide.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking lisinopril and hydrochlorothiazide.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Source
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.
