Rolapitant is used along with other medications to prevent nausea and vomiting that may occur several days after receiving certain chemotherapy medications. Rolapitant is in a class of medications called antiemetics. It works by blocking the action of neurokinin and substance P, natural substances in the brain that cause nausea and vomiting.
Side Effects Of Rolapitant
Rolapitant may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- stomach pain
- decreased appetite
- mouth sores
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- fever, chills, sore throat, or other signs of an infection
Rolapitant may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Warnings & Precautions
Before taking rolapitant:
- tell your doctor and pharmacist if you are allergic to rolapitant, any other medications, or any of the ingredients in rolapitant tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking thioridazine or pimozide (Orap). Your doctor will probably tell you not to take rolapitant if you are taking one or more of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: dextromethorphan (Robitussin, others), digoxin (Lanoxin), irinotecan (Camptosar), methotrexate (Otrexup, Rasuvo, Trexall), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), rosuvastatin (Crestor), and topotecan (Hycamtin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with rolapitant, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you have or have ever had liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking rolapitant, call your doctor.
Dosage Of Rolapitant
Rolapitant comes as a tablet to take by mouth. It is usually taken as a single dose within 2 hours before the start of chemotherapy. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take rolapitant exactly as directed.
Do not take rolapitant more than once every 14 days.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Keep all appointments with your doctor.
Do not let anyone else take your medication.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.