Moxifloxacin Injection


Moxifloxacin injection is used to treat certain infections caused by bacteria such as pneumonia; and skin and abdominal (stomach area) infections. Moxifloxacin injection is also used to prevent and treat plague (a serious infection that may be spread on purpose as part of a bioterror attack. Moxifloxacin injection may also be used to treat bronchitis or sinus infections but should not be used for these conditions if there are other treatment options available. Moxifloxacin injection is in a class of antibiotics called fluoroquinolones. It works by killing the bacteria that cause infections.

Antibiotics such as moxifloxacin injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Side Effects Of Moxifloxacin Injection

Moxifloxacin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • stomach pain
  • diarrhea
  • constipation
  • heartburn
  • irritation, pain, tenderness, redness, warmth, or swelling at the injection spot

If you experience any of the following symptoms or any of the symptoms described in the WARNING section, stop using moxifloxacin injection and call your doctor immediately or get emergency medical help:

  • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)
  • rash
  • hives
  • itching
  • peeling or blistering of the skin
  • fever
  • swelling of the eyes, face, mouth, lips, tongue, throat, hands, feet, ankles, or lower legs
  • hoarseness or throat tightness
  • difficulty breathing or swallowing
  • ongoing or worsening cough
  • yellowing of the skin or eyes; pale skin; dark urine; or light-colored stool
  • extreme thirst or hunger; pale skin; feeling shaky or trembling; fast or fluttering heartbeat; sweating; frequent urination; trembling; blurred vision; or unusual anxiety
  • fainting or loss of consciousness
  • unusual bruising or bleeding
  • sudden pain in the chest, stomach, or back
  • Moxifloxacin injection may cause problems with bones, joints, and tissues around joints in children. Moxifloxacin injection should not be given to children younger than 18 years of age.

Moxifloxacin injection may cause other side effects

Warnings & Precautions

Before taking moxifloxacin injection:

  • tell your doctor and pharmacist if you are allergic to moxifloxacin injection (rash, hives, shortness of breath, swelling of the face, eyes, mouth, throat, tongue, lips, hands, feet, ankles, or lower legs), leflunomide (Arava), any other medications, or any of the ingredients in moxifloxacin injection tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor if you are taking leflunomide (Arava). Your doctor will probably tell you not to take moxifloxacin injection if you are taking this medication.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take with moxifloxacin injection. Be sure to mention the medications listed in the WARNING section and any of the following: alosetron (Lotronex); anticoagulants (‘blood thinners’) such as warfarin (Coumadin, Jantoven); atorvastatin (Lipitor, in Caduet); cefaclor; cimetidine (Tagamet); ciprofloxacin (Cipro); duloxetine (Cymbalta); eltrombopag (Promacta); furosemide (Lasix); gefitinib (Iressa); ketoprofen; medications that can cause nerve damage such as medications for cancer, HIV, or AIDS; other medications that suppress the immune system such as azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Astagraf, Envarsus XR, Prograf); methotrexate (Otrexup, Rasuvo, Trexall); mitoxantrone; nateglinide (Starlix); oral contraceptives (birth control pills); paclitaxel (Abraxane, Taxol); penicillin G; pioglitazone (Actos, in Actoplus Met, in Duetact); pravastatin (Pravachol); repaglinide (Prandin, in Prandimet); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); rosiglitazone (Avandia); rosuvastatin (Crestor); simvastatin (Zocor, in Vytorin); theophylline (Elixophyllin, Theo-24, Uniphyl, others); tizanidine (Zanaflex); and zidovudine (Retrovir, in Combivir, in Trizivir). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with moxifloxacin injection, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • tell your doctor if you have an infection now, including an ongoing infection that does not go away, or if you have or have ever had a serious skin reaction after you took another medication; diabetes; breathing problems; cancer, or other conditions affecting the bone marrow or the immune system; high blood pressure; peripheral neuropathy (numbness, burning or tingling in the hands or feet that feels different from your MS symptoms); or kidney disease.
  • tell your doctor if you are breast-feeding. Do not breastfeed while taking this medication.
  • if your partner plans to become pregnant, you should talk to your doctor about stopping moxifloxacin injection and receiving a treatment to help remove this medication from your body more quickly. If your partner does not plan to become pregnant, you and your partner should use an effective method of birth control during your treatment with moxifloxacin injection and for up to 2 years after treatment, until blood tests show that you have low enough levels of moxifloxacin injection in your blood.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking moxifloxacin injection.
  • you may already be infected with tuberculosis (TB; a serious lung infection) but not have any symptoms of the disease. Tell your doctor if you have or have ever had TB, if you have lived in or visited a country where TB is common, or if you have been around someone who has or has ever had TB. Before you begin your treatment with moxifloxacin injection, your doctor will perform a skin test to see if you have TB. If you do have TB, your doctor will treat this infection before you begin taking moxifloxacin injection.
  • do not have any vaccinations without talking to your doctor while you are taking moxifloxacin injection and for 6 months after you stop taking it.
  • you should know that moxifloxacin injection may cause high blood pressure. You should have your blood pressure checked before starting treatment and regularly while you are taking this medication.

Dosage Of Moxifloxacin Injection

This medication comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take moxifloxacin injection at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take the medication exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Moxifloxacin injection may help to control the symptoms of multiple sclerosis but does not cure it. Continue to take moxifloxacin injection even if you feel well. Do not stop taking moxifloxacin injection without talking to your doctor.


Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription of moxifloxacin injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.