Fosamprenavir

Fosamprenavir
Fosamprenavir

Uses

Fosamprenavir is used along with other medications to treat human immunodeficiency virus (HIV) infection. Fosamprenavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although fosamprenavir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting the HIV virus to other people.

Side Effects Of Fosamprenavir

Fosamprenavir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea
  • nausea
  • vomiting
  • headache
  • extreme tiredness

Some side effects can be serious. If you experience any of these symptoms after taking fosamprenavir, call your doctor immediately or get emergency medical treatment.

Fosamprenavir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before taking fosamprenavir:

  • tell your doctor and pharmacist if you are allergic to fosamprenavir, amprenavir (Agenerase; no longer available in the U.S.), sulfa medications, any other medications, or any of the ingredients in fosamprenavir tablets or suspension. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you are taking alfuzosin (Uroxatral); cisapride (Propulsid) (not available in the US); delavirdine (Rescriptor); ergot medications such as dihydroergotamine (D.H.E. 45, Migranal), ergoloid mesylates (Hydergine), ergonovine, ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); lomitapide (Juxtapid); lovastatin (Altoprev); midazolam (Versed); pimozide (Orap); rifampin (Rifadin, Rimactane, in Rifater, in Rifamate); sildenafil (only Revatio brand used for lung disease); simvastatin (Zocor, in Vytorin); St. John’s wort; or triazolam (Halcion). Your doctor will probably tell you not to take fosamprenavir if you are taking one or more of these medications.
  • do not take flecainide, lurasidone (Latuda), or propafenone (Rhythmol) if you are taking fosamprenavir and ritonavir (Norvir) together.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking. Be sure to mention any of the following: anticoagulants (‘blood thinners’) such as warfarin (Coumadin, Jantoven); antidepressants such as amitriptyline, imipramine (Surmontil), paroxetine (Brisdelle, Paxil, Pexeva), and trazodone; atorvastatin (Lipitor, in Caduet); antacids containing aluminum and magnesium (Maalox, others); benzodiazepines such as alprazolam (Xanax), clorazepate (Gen-Xene, Tranxene), diazepam (Diastat, Valium), and flurazepam; bosentan (Tracleer); calcium channel blockers such as amlodipine (Norvasc, in Exforge, others), diltiazem (Cardizem, Cartia, Tiazac, others), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), nimodipine (Nymalize), nisoldipine (Sular), and verapamil (Calan, Covera, Verelan, in Tarka); colchicine (Colcrys, Mitigare); dasatinib (Sprycel); dexamethasone; everolimus (Afinitor); fentanyl (Duragesic); fluticasone (hepatitis C virus including boceprevir (no longer available in U.S.; Victrelis), paritaprevir (in Viekira XR), and simeprevir (no longer available in U.S.; Olysio); certain phosphodiesterase inhibitors (PDE-5 inhibitors) used for erectile dysfunction such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra); quetiapine (Seroquel); rifabutin (Mycobutin); salmeterol (Serevent, in Advair); tadalafil (Adcirca); and vinblastine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with fosamprenavir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • tell your doctor if you have or have ever had diabetes, hemophilia (a disease in which the blood does not clot normally), high cholesterol or triglycerides, or kidney or liver disease, including hepatitis B or C.
  • tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking fosamprenavir, call your doctor. You should not breast-feed if you are infected with HIV or are taking fosamprenavir.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking fosamprenavir.
  • you should know that fosamprenavir may decrease the effectiveness of oral contraceptives (birth control pills). Talk to your doctor about other ways to prevent pregnancy while you are taking this medication.
  • you should know that your body fat may increase or move to different areas of your body such as your breasts and upper back.
  • you should know that you may experience hyperglycemia (increases in your blood sugar) while you are taking this medication, even if you do not already have diabetes. Tell your doctor immediately if you have any of the following symptoms while you are taking fosamprenavir: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very important to call your doctor as soon as you have any of these symptoms because high blood sugar that is not treated can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness.
  • you should know that while you are taking medications to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body. This may cause you to develop symptoms of those infections. If you have new or worsening symptoms at any time during your treatment with fosamprenavir, be sure to tell your doctor.

Fosamprenavir Dosage

Fosamprenavir comes as a tablet and a suspension (liquid) to take by mouth. It is usually taken once or twice a day. The tablets can be taken with or without food. In patients at least 18 years old, the suspension should be taken without food. In patients younger than 18 years old, the suspension should be taken with food. To help you remember to take fosamprenavir, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take fosamprenavir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are taking the suspension, shake it well before each use to mix the medication evenly.

If you vomit less than 30 minutes after you take fosamprenavir, you should take another full dose of fosamprenavir.

Fosamprenavir controls HIV infection but does not cure it. Continue to take fosamprenavir even if you feel well. Do not stop taking fosamprenavir without talking to your doctor. If you miss doses or stop taking fosamprenavir, your condition may become more difficult to treat.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

Other

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests before and during your treatment to be sure it is safe for you to take fosamprenavir and to check your body’s response to fosamprenavir.

Do not run out of medication. When your supply of fosamprenavir starts to run low, get more from your doctor or pharmacist.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Source

All information on fosamprenavir has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.