Vinorelbine Injection


Vinorelbine injection is used alone and in combination with other medications to treat non-small cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body.

Vinorelbine is in a class of medications called vinca alkaloids. It works by slowing or stopping the growth of cancer cells in your body.

Side Effects Of Vinorelbine Injection

Vinorelbine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • diarrhea
  • loss of appetite
  • weight loss
  • change in the ability to taste food
  • sores in the mouth and throat
  • hearing loss
  • muscle, or joint pain
  • hair loss
  • lack of energy, not feeling well, tiredness

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

  • shortness of breath or difficulty breathing, cough
  • constipation, stomach pain, nausea, vomiting
  • unusual bleeding or bruising
  • hives, itching, rash, difficulty breathing or swallowing
  • swelling of the face, throat, tongue, lips, and eyes
  • blistering or peeling skin
  • yellowing of skin or eyes, dark-colored urine, light-colored stool
  • numbness, tingling feeling on the skin, sensitive skin, decreased sense of touch, or muscle weakness
  • fever, chills, sore throat, or other signs of infection
  • chest pain, shortness of breath, coughing up blood
  • red, swollen, tender, or warm arm or leg
  • Talk to your doctor about the risks of receiving vinorelbine injection.

Vinorelbine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before receiving vinorelbine:

  • tell your doctor and pharmacist if you are allergic to vinorelbine, any other medications, or any of the ingredients in vinorelbine injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antifungals such as itraconazole (Onmel, Sporanox, Tolsura) and ketoconazole; clarithromycin ; HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, Technivie, Viekira), and saquinavir (Invirase); or nefazodone. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had liver disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or plan to father a child. You or your partner should not become pregnant while you are receiving vinorelbine injection. You must take a pregnancy test before you start treatment to be sure you are not pregnant. If you are a female, use effective birth control during your treatment and for 6 months after your final dose. If you are a male, use effective birth control during your treatment and for 3 months after your final dose. If you or your partner become pregnant while you’re receiving vinorelbine injection, call your doctor. Vinorelbine may harm the fetus.
  • tell your doctor if you are breast-feeding. Your doctor will probably tell you not to breastfeed during your treatment and for 9 days after your final dose.
  • you should know that vinorelbine may cause constipation. Talk to your doctor about changing your diet and using other medications to prevent or treat constipation while you are taking vinorelbine.

Vinorelbine Injection Dosage

Vinorelbine comes as a solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given once a week. The length of treatment depends on how well your body responds to treatment with vinorelbine.

You should know that vinorelbine should be administered only into a vein. However, it may leak into surrounding tissue causing severe irritation or damage. Your doctor or nurse will monitor the area near where the medication was injected. If you experience any of the following symptoms, tell your doctor immediately: pain, itching, redness, swelling, blisters, or sores near the place where the medication was injected.


It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.