Floxuridine is used to treat cancer of gastrointestinal (GI) tract (cancer of the stomach or intestines) that has spread to the liver. Floxuridine is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in your body.

Side Effects Of Floxuridine

Floxuridine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • loss of appetite or weight
  • diarrhea
  • abdominal pain
  • dry, red, and itchy skin
  • hair loss
  • pain, itching, redness, swelling, blisters, bleeding, or sores in the place where the medication was injected

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • sores in the mouth and throat
  • extreme tiredness or weakness
  • fever, sore throat, ongoing cough, and congestion, or other signs of infection
  • unusual bleeding or bruising
  • bloody or black, tarry stools
  • bloody vomit; or vomiting blood or brown material that resembles coffee grounds
  • pink, red, or dark brown urine
  • chest pain
  • hives
  • difficulty breathing or swallowing
  • Floxuridine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before receiving floxuridine:

  • tell your doctor and pharmacist if you are allergic to floxuridine, fluorouracil, any other medications, or any of the ingredients in floxuridine injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: medications that suppress the immune system such as azathioprine (Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex), sirolimus (Rapamune), and tacrolimus (Prograf). Your doctor may need to monitor you carefully for side effects. Many other medications may also interact with floxuridine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • tell your doctor if you have an infection or are not able to eat enough or a good balance of food. Your doctor may not want you to receive floxuridine injection.
  • tell your doctor if you have previously received radiation (x-ray) therapy or treatment with other chemotherapy medications or if you have or have ever had kidney or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not become pregnant or breast-feed while you are receiving floxuridine injection. If you become pregnant while receiving floxuridine injection, call your doctor. Floxuridine may harm the fetus.

Floxuridine Dosage

Floxuridine comes as a powder to be mixed with liquid to be continuously injected intra-arterially (into an artery) that supplies blood to the tumor.


Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body’s response to floxuridine.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.