Perampanel is used to treat certain types of partial onset seizures (seizures that involve only one part of the brain) in adults and children 4 years of age and older. It is also used in combination with other medications to treat certain types of primary generalized tonic-clonic seizures (formerly known as a grand mal seizure; seizure that involves the entire body) in adults and children 12 years of age or older. Perampanel is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.

Side Effects Of Perampanel

Perampanel may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dizziness or a sense of spinning
  • drowsiness
  • constipation
  • nausea
  • vomiting
  • headache
  • tiredness
  • weight gain
  • irritability
  • weakness
  • problems with coordination
  • muscle, back, or joint pain
  • decreased sense of touch or sensation
  • blurred or double vision

Some side effects can be serious. If you experience any of these symptoms or those listed in the WARNINGS AND PRECAUTIONS sections, stop taking perampanel and call your doctor immediately or get emergency medical treatment:

  • rash; hives; fever or swollen glands; swelling of your face or legs; shortness of breath; yellow of skin or eyes; or dark urine
  • Perampanel may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before taking perampanel:

  • tell your doctor and pharmacist if you are allergic to perampanel, any other medications, or any of the ingredients in perampanel tablets or oral suspension. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: antidepressants; barbiturates such as phenobarbital and secobarbital (Seconal); medications for allergies, anxiety, cough and cold, mental illness, and pain; medications for seizures such as carbamazepine (Carbatrol, Tegretol, Equetro), oxcarbazepine (Trileptal, Oxtellar), phenytoin (Dilantin, Phenytek), primidone (Mysoline), and topiramate (Topamax); rifampin (Rifadin); sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with perampanel, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • you should know that perampanel may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or implants) that contain levonorgestrel. Use another form of birth control while taking perampanel and for 1 month after your final dose. Ask your doctor or pharmacist if you are not sure if your birth control contains levonorgestrel.
  • tell your doctor what herbal products you are taking, especially St. John’s wort.
  • tell your doctor if you drink or have ever drunk large amounts of alcohol, if you use or have ever used street drugs, or if you have overused prescription medications. Also, tell your doctor if you have or have ever had kidney or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking perampanel, call your doctor.
  • you should know that perampanel may cause dizziness, drowsiness, and problems with coordination and balance. This may increase the risk of falls that can cause serious injury, especially if you are elderly. Do not drive a car, operate machinery, or participate in activities requiring alertness or coordination until you know how this medication affects you.
  • ask your doctor about the safe use of alcoholic beverages while you are taking perampanel. Alcohol can make the side effects of perampanel worse.
  • you should know that your mental health may change in unexpected ways and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking perampanel. A small number of adults and children 5 years of age and older (about 1 in 500 people) who took anticonvulsants like perampanel to treat various conditions during clinical studies became suicidal during their treatment. Some of these people developed suicidal thoughts and behavior as early as 1 week after they started taking the medication. There is a risk that you may experience changes in your mental health if you take an anticonvulsant medication such as perampanel, but there may also be a risk that you will experience changes in your mental health if your condition is not treated. You and your doctor will decide whether the risks of taking an anticonvulsant medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling asleep or staying asleep; aggressive, angry, or violent behavior; mania (frenzied, abnormally excited mood); talking or thinking about wanting to hurt yourself or end your life; or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

Perampanel Dosage

Perampanel comes as a tablet and as a suspension (liquid) to take by mouth. It is usually taken once a day at bedtime. Take perampanel at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take perampanel exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the suspension well before each use to mix the medication evenly.

Always use the oral (by mouth) dosing syringe that comes with perampanel suspension to prepare and measure your dose. Do not use a household spoon to measure your dose.

Your doctor will probably start you on a low dose of perampanel and gradually increase your dose, not more than once every week.

Perampanel may be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.

Perampanel may help control your condition but does not cure it. Do not stop taking perampanel without talking to your doctor. If you suddenly stop taking perampanel, your seizures may become worse. Your doctor will probably decrease your dose gradually.


Keep all appointments with your doctor.

Do not let anyone else take your medication. Perampanel is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.