Uses of Aldesleukin
Aldesleukin is used to treat advanced renal cell carcinoma (RCC, a type of cancer that begins in the kidney) that has spread to other parts of your body. Aldesleukin is also used to treat melanoma (a type of skin cancer) that has spread to other parts of your body. Aldesleukin is in a class of drugs known as cytokines. It is a man-made version of a naturally occurring protein that stimulates the body to produce other chemicals which increase the body’s ability to fight cancer.
Side Effects of Aldesleukin
Aldesleukin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- loss of appetite
- sores in the mouth and throat
- general feeling of being unwell
- pain or redness at the place where the injection was given
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
- chest pain
- extreme worry
- abnormal excitement or agitation
- new or worsening depression
- seeing things or hearing voices that do not exist (hallucinating)
- changes in your vision or speech
- loss of coordination
- decreased alertness
- unusual bruising or bleeding
- extreme sleepiness or tiredness
- difficulty breathing
- stomach pain
- yellowing of the skin or eyes
- decreased urination
- difficulty breathing or swallowing
Aldesleukin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Warnings & Precautions
Before receiving aldesleukin:
- tell your doctor and pharmacist if you are allergic to aldesleukin, any other medications, or any of the ingredients in aldesleukin injection. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); certain cancer chemotherapy medications such as asparaginase (Elspar), cisplatin (Platinol), dacarbazine (DTIC-dome), doxorubicin (Doxil), interferon-alfa (Pegasys, PEG-Intron), methotrexate (Rheumatrex, Trexall), and tamoxifen (Nolvadex); medications for high blood pressure; medications for nausea and vomiting; narcotics and other pain medications; sedatives, sleeping pills, and tranquilizers; steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); and steroid creams, lotions, or ointments such as hydrocortisone (Cortizone, Westcort). Also tell your doctor and pharmacist about all the medications you are taking so they can check whether any of your medications may increase the risk that you will develop kidney or liver damage during your treatment with aldesleukin.
- tell your doctor if you have ever had seizures, gastrointestinal (GI) bleeding requiring surgical treatment, or other serious GI, heart, nervous system, or kidney problems after you received aldesleukin or if you have ever had an organ transplant (surgery to replace an organ in the body). Your doctor may not want you to receive aldesleukin.
- tell your doctor if you have or have ever had seizures, Crohn’s disease, scleroderma (a disease that affects the tissues that support skin and internal organs), thyroid disease, arthritis, diabetes, myasthenia gravis (a disease that weakens muscles), or cholecystitis (inflammation of the gall bladder that causes severe pain).
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving aldesleukin, call your doctor. You should not breast-feed while receiving aldesleukin.
Aldesleukin comes as a powder to be mixed with liquid to be injected over intravenously (into a vein) over 15 minutes by a doctor or nurse in a hospital. It is usually injected every 8 hours for 5 days in a row (a total of 14 injections). This cycle may be repeated after 9 days. The length of treatment depends on how well your body responds to treatment.
Your doctor may need to delay or permanently stop your treatment if you experience certain side effects. You will be carefully monitoring during your treatment with aldesleukin. It is important for you to tell your doctor how you are feeling during your treatment with aldesleukin.
If you are having x-rays, tell the doctor that you are receiving aldesleukin therapy.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.