Solriamfetol is used to treat excessive daytime sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness). Solriamfetol is also used along with breathing devices or other treatments to prevent excessive daytime sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS; a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore doesn’t get enough restful sleep). Solriamfetol is in a class of medications called wakefulness promoting agents. It works by increasing the amounts of certain natural substances in the brain that controls sleep and wakefulness.

Side Effects Of Solriamfetol

Solriamfetol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • dizziness
  • difficulty falling asleep or staying asleep
  • nausea
  • diarrhea
  • constipation
  • loss of appetite
  • stomach pain
  • sweating

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • chest pain
  • fast, pounding, or irregular heartbeat
  • shortness of breath
  • slow or difficult speech
  • weakness or numbness of an arm or leg
  • changes in vision or blurred vision
  • increased tiredness
  • swelling of the hands, feet, ankles, or lower legs
  • frenzied, abnormally excited mood
  • anxiety
  • irritability
  • agitation
  • aggressive behavior
  • hallucinating (seeing things or hearing voices that do not exist)

Solriamfetol may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before taking solriamfetol:

  • tell your doctor and pharmacist if you are allergic to solriamfetol, any other medications, or any of the ingredients in solriamfetol tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you are taking monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), Rasagiline (Azilect), Safinamide (Xadago), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking them during the past 14 days. Your doctor will probably tell you not to take solriamfetol until at least 14 days have passed since you last took an MAO inhibitor.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: dopamine agonists such as bromocriptine (Cycloset, Parlodel), cabergoline, levodopa (Inbrija, in Rytary, in Sinemet, in Stalevo), and ropinirole (Requip); medications for asthma and colds; and medications for mental illness and nausea. Many other medications may also interact with solriamfetol, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications, especially stimulants. Also, tell your doctor if you have ever had high blood pressure; a stroke; high cholesterol; chest pain, an irregular heartbeat, a heart attack, or other heart problems; a mental illness such as depression, bipolar disorder (mood that changes from depressed to abnormally excited), mania (frenzied, abnormally excited mood), or psychosis (difficulty thinking clearly, communicating, understanding reality, and behaving appropriately); diabetes, or kidney problems.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking modafinil, call your doctor.
  • you should know that solriamfetol may cause an increase in your blood pressure. Your doctor may check your blood pressure before starting treatment and regularly while you are taking this medication.
  • you should know that solriamfetol may not completely relieve the sleepiness caused by your disorder. Do not drive a car or operate machinery until you know how this medication affects you. If you avoided driving and other dangerous activities because of your sleep disorder, do not start performing these activities again without talking to your doctor even if you feel more alert.

Dosage Of Solriamfetol

Solriamfetol comes as a tablet to take by mouth. It is usually taken once a day with or without food as soon as you wake up in the morning. Take solriamfetol at the same time every day. Do not take solriamfetol within 9 hours before you plan to go to bed because it may cause difficulty falling asleep or staying asleep. Do not change the time of day that you take solriamfetol without talking to your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take solriamfetol exactly as directed.

Your doctor will probably start you on a low dose of solriamfetol and gradually increase your dose, not more than once every 3 days.

Solriamfetol may be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.

Solriamfetol may decrease your sleepiness, but it will not cure your sleep disorder. Continue to take solriamfetol even if you feel well-rested. Do not stop taking solriamfetol without talking to your doctor.

Solriamfetol should not be used in place of getting enough sleep. Follow your doctor’s advice about good sleep habits. Continue to use any breathing devices or other treatments that your doctor has prescribed to treat your condition, especially if you have OSAHS.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.


Keep all appointments with your doctor.

Do not let anyone else take your medication. Selling or giving away solriamfetol is against the law. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.