Dacarbazine is used to treat melanoma (a type of skin cancer) that has spread to other parts of your body. Dacarbazine is also used in combination with other medications to treat Hodgkin’s lymphoma (Hodgkin’s disease; a type of cancer that begins in a type of white blood cells that normally fights infection). Dacarbazine is in a class of medications known as purine analogs. It works by slowing or stopping the growth of cancer cells in your body.
Side Effects Of Dacarbazine
Dacarbazine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- loss of appetite
- sores in the mouth and throat
- hair loss
- a feeling of burning or tingling on the face
- flu-like symptoms
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
- redness, pain, swelling or burning at the site where the injection was given
- skin rash
- difficulty breathing or swallowing
- fever, muscle aches, and the general feeling of pain and tiredness
Dacarbazine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Warnings & Precautions
Before receiving dacarbazine:
- tell your doctor and pharmacist if you are allergic to dacarbazine, any other medications, or any of the ingredients in dacarbazine injection. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
- tell your doctor if you are breast-feeding.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Dacarbazine may make your skin sensitive to sunlight.
Dosage Of Dacarbazine
Dacarbazine injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) over 1 minute or infused intravenously over 15 to 30 minutes by a doctor or nurse in a medical facility. When dacarbazine is used to treat melanoma, it may be injected once a day for 10 days in a row every 4 weeks or it may be injected once a day for 5 days in a row every 3 weeks. When dacarbazine is used to treat Hodgkin’s lymphoma is may be injected once a day for 5 days in a row every 4 weeks or it may be injected once every 15 days.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.