Mesna is used to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in serious bleeding) in people who receive ifosfamide (a medication used for the treatment of cancer). Mesna is in a class of medications called cytoprotectants. It works by protecting the bladder against some of the harmful effects of certain chemotherapy medications.

Side Effects Of Mesna

Mesna may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • constipation
  • loss of appetite or weight
  • diarrhea
  • abdominal pain
  • headache
  • tiredness
  • dizziness
  • hair loss
  • loss of strength and energy
  • fever
  • sore throat
  • cough
  • flushing
  • the sensitivity of the skin to touch

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

Mesna may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before taking mesna:

  • tell your doctor and pharmacist if you are allergic to mesna, any other medications, or any of the ingredients in mesna tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
  • tell your doctor if you have or have ever had an autoimmune disorder (conditions in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage) such as rheumatoid arthritis, systemic lupus erythematosus, or nephritis (a type of kidney problem).
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.

Dosage Of Mesna

Mesna comes as a tablet to take by mouth. The first dose of mesna is usually given as an injection into your vein at the same time as you receive your chemotherapy treatment. After that, your doctor may choose to continue your treatment with mesna tablets. It is usually given 2 and 6 hours after your chemotherapy treatment. Take mesna exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you vomit less than 2 hours after you take a dose of mesna tablets, call your doctor right away.

Drink at least 1 quart (4 cups; about 1 liter) of liquid daily while you are taking mesna tablets.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.


Keep all appointments with your doctor and the laboratory.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking mesna.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.