Maprotiline is used to treat depression, bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods), and anxiety. Maprotiline is in a class of medications called tetracyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance.
Side Effects Of Maprotiline
Maprotiline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- weakness or tiredness
- dry mouth
- skin more sensitive to sunlight than usual
- changes in appetite or weight
- difficulty urinating
- frequent urination
- blurred vision
- changes in sex drive or ability
- excessive sweating
Some side effects can be serious. If you experience any of the following symptoms or those listed in the WARNINGS and PRECAUTIONS section, call your doctor immediately:
- jaw, neck, and back muscle spasms
- slow or difficult speech
- shuffling walk
- uncontrollable shaking of a part of the body
- fever, chills, sore throat, or flu-like symptoms
- difficulty breathing or swallowing
- yellowing of the skin or eyes
- irregular heartbeat
Maprotiline may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
Warnings & Precautions
Before taking maprotiline:
- tell your doctor and pharmacist if you are allergic to maprotiline or any other medications.
- tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have taken an MAO inhibitor during the past 14 days. Your doctor will probably tell you that you should not take maprotiline.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants (blood thinners) such as warfarin (Coumadin); antihistamines; estrogens; fluoxetine (Prozac); levodopa (Sinemet, Larodopa); lithium (Eskalith, Lithobid); medication for high blood pressure, seizures, Parkinson’s disease, asthma, colds, or allergies; methylphenidate (Ritalin); muscle relaxants; oral contraceptives; sedatives; sleeping pills; thyroid medication; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had glaucoma (an eye condition), an enlarged prostate (a male reproductive gland), difficulty urinating, seizures, a brain tumor, a head injury, an overactive thyroid gland, or liver, kidney, or heart disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking maprotiline, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking maprotiline.
- you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
- remember that alcohol can add to the drowsiness caused by this medication.
- tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.
Dosage Of Maprotiline
Maprotiline comes as a tablet to take by mouth. It is usually taken one to three times a day and may be taken with or without food. Take maprotiline at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take maprotiline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
It may take a few weeks or longer for you to feel the full benefit of maprotiline. Continue to take maprotiline even if you feel well. Do not stop taking maprotiline without talking to your doctor. Your doctor will probably want to decrease your dose gradually.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to maprotiline.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.