Uses
Bismuth, metronidazole, and tetracycline is used along with other ulcer medications to treat duodenal ulcers. It is in a class of medications called antibacterial agents. It works by preventing the growth and spread of Helicobacter pylori bacteria, which often occurs with ulcers. Treating this infection keeps ulcers from coming back.
Side Effects Of Bismuth, Metronidazole, And Tetracycline
Bismuth, metronidazole, and tetracycline may cause side effects. Darkening of the tongue and stool is temporary and harmless. Tell your doctor if any of these symptoms are severe or do not go away:
- weakness
- diarrhea
- constipation
- dark urine
- loss of appetite
- stomach pain
- heartburn
- metallic taste in the mouth
- dry or sore mouth
If you have any of the following symptoms, stop taking this medication and call your doctor immediately:
- numbness, pain, burning or tingling in your hands or feet
- headache
- blurred vision
- seizures
- dizziness
- difficulty speaking
- problems with coordination
- confusion or agitation
- ringing in the ears
- vaginal itching and/or discharge
- fever, cough, sore throat, chills, or other signs of infection
- bloody or tarry stools
- nausea
- vomiting
- hives
- rash
- itching
Warnings & Precautions
Before taking bismuth, metronidazole, and tetracycline:
- tell your doctor and pharmacist if you are allergic to bismuth, metronidazole (Flagyl), aspirin or salicylates, doxycycline (Doryx, Vibramycin), minocycline (Dynacin, Minocin), tetracycline (Sumycin), tinidazole (Tindamax), any other medications, or any of the ingredients in bismuth, metronidazole, and tetracycline combination. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking or have taken disulfiram (Antabuse). Your doctor may tell you not to take bismuth, metronidazole, and tetracycline if you are taking disulfiram (Antabuse) or have taken it within the past two weeks.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antibiotics such as penicillin, anticoagulants (‘blood thinners’) such as warfarin (Coumadin, Jantoven), aspirin or aspirin-containing products, astemizole (Hismanal) (not available in the US), cimetidine (Tagamet), lithium (Eskalith, Lithobid), medications for diabetes, omeprazole (Prilosec, Zegerid), oral contraceptives, phenobarbital (Luminal), phenytoin (Dilantin, Phenytek), probenecid (in Col-probenecid, Probalan), sulfinpyrazone (Anturane), and terfenadine (Seldane) (not available in the US). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- if you are taking antacids containing aluminum, calcium, magnesium or sodium bicarbonate, or zinc supplements, take them 1 to 2 hours before or 1 to 2 hours after bismuth, metronidazole, and tetracycline. If you are taking iron supplements, take them 3 hours before or 2 hours after bismuth, metronidazole, and tetracycline.
- tell your doctor if you have kidney or liver disease. Your doctor may tell you not to take this medication.
- tell your doctor if you have an infection or if you have or have ever had blood problems, Crohn’s disease, or central nervous system conditions.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking this medication, call your doctor. Tetracycline can cause birth defects and may harm nursing babies.
- you should know that this medication may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, injections, and intrauterine devices). Use another form of birth control while you are taking this medication. Talk to your doctor about types of birth control that will work for you during and after your treatment with bismuth, metronidazole, and tetracycline.
- remember not to drink alcoholic beverages or take products with alcohol or propylene glycol while taking this medication and for at least 3 days after treatment is finished. Alcohol and propylene glycol may cause nausea, vomiting, stomach cramps, headache, sweating, and flushing (redness of the face) when taken during treatment with metronidazole.
- plan to avoid unnecessary or prolonged exposure to sunlight or ultraviolet light (tanning beds and sun lamps) and to wear protective clothing, sunglasses, and sunscreen. This medication may make your skin sensitive to sunlight.
- you should know that when tetracycline is taken during pregnancy or by babies or children up to age 8, it can cause the teeth to become permanently stained and to not form properly. It may also keep bones from developing properly. Tetracycline should not be taken by children under age 8.
Dosage Of Bismuth, Metronidazole, And Tetracycline
Bismuth, metronidazole, and tetracycline (Helidac) comes as two chewable bismuth tablets, one metronidazole tablet, and one tetracycline capsule to take together by mouth. Bismuth, metronidazole, and tetracycline (Pylera) come as a capsule to take by mouth. It usually is taken four times a day, at meals and at bedtime for 10 days (Pylera) or 14 days (Helidac). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take this medication exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are taking bismuth, metronidazole, and tetracycline (Helidac), chew and swallow the bismuth tablets. Swallow the metronidazole tablet and tetracycline capsule whole with a full glass of water (8 ounces [240 milliliters]). If you are taking bismuth, metronidazole, and tetracycline (Pylera), swallow the capsules whole with a full glass of water (8 ounces [240 milliliters]). It is especially important to take the bedtime dose with plenty of fluid to prevent irritation of your throat and stomach.
Take bismuth, metronidazole, and tetracycline at least 1 hour before or 2 hours after you eat or drink foods that contain calcium, such as dairy products and calcium-fortified juices and foods.
Continue to take this medication even if you feel well. Do not stop taking it without talking to your doctor. If you stop taking this medication too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Other
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to this medication.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking this medication.
Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of an ulcer after you finish this medication, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Source
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.
