Nitroglycerin Transdermal Patch

Nitroglycerin Transdermal Patch
Nitroglycerin Transdermal Patch


Nitroglycerin transdermal patches are used to prevent episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Nitroglycerin transdermal patches can only be used to prevent attacks of angina; they cannot be used to treat an attack of angina once it has begun. Nitroglycerin is in a class of medications called vasodilators. It works by relaxing the blood vessels so that the heart does not need to work as hard and therefore does not need as much oxygen.

Side Effects Of Nitroglycerin Transdermal Patch

Nitroglycerin patches may cause side effects. Tell your doctor if any of these symptoms or those listed in the WARNINGS and PRECAUTIONS section are severe or do not go away:

  • redness or irritation of the skin that was covered by the patch
  • flushing

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

Nitroglycerin patches may cause other side effects. Call your doctor if you have any unusual problems while you are using this medication.

Warnings & Precautions

Before using nitroglycerin patches:

  • tell your doctor and pharmacist if you are allergic to nitroglycerin patches, tablets, spray, or ointment; any other medications; adhesives; or any of the ingredients in nitroglycerin skin patches. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you are taking riociguat (Adempas) or if you are taking or have recently taken a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). Your doctor will probably tell you not to use nitroglycerin patches if you are taking any of these medications.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aspirin; beta-blockers such as atenolol (Tenormin), carteolol , labetalol (Trandate), metoprolol (Lopressor), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), and timolol; calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem), felodipine (Plendil), isradipine (DynaCirc), nifedipine (Procardia), and verapamil (Calan, Isoptin); ergot-type medications such as bromocriptine (Parlodel), cabergoline, dihydroergotamine (D.H.E. 45, Migranal), ergoloid mesylates (Hydergine), ergonovine (Ergotrate), ergotamine (Cafergot), methylergonovine (Methergine), methysergide (Sansert), and pergolide (Permax); medications for high blood pressure, heart failure, or an irregular heartbeat. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you think you may be dehydrated, if you have recently had a heart attack, and if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (thickening of the heart muscle).
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using nitroglycerin patches, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are using nitroglycerin transdermal patches.
  • ask your doctor about the safe use of alcoholic beverages while you are using nitroglycerin skin patches. Alcohol can make the side effects of nitroglycerin patches worse.
  • you should know that nitroglycerin transdermal patches may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. To avoid this problem, get up slowly, resting your feet on the floor for a few minutes before standing up. Take extra precautions to avoid falling during your treatment with nitroglycerin patches.
  • you should know that you may experience headaches every day during your treatment with nitroglycerin patches. These headaches may be a sign that the medication is working as it should. Do not try to change the times or the way that you apply nitroglycerin patches to avoid headaches because then the medication may not work as well. Your doctor may tell you to take a pain reliever to treat your headaches.

Nitroglycerin Transdermal Patch Dosage

Transdermal nitroglycerin comes as a patch to apply to the skin. It is usually applied once a day, worn for 12 to 14 hours, and then removed. Apply nitroglycerin patches at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use nitroglycerin patches exactly as directed. Do not apply more or fewer patches or apply the patches more often than prescribed by your doctor.

Choose a spot on your upper body or upper arms to apply your nitroglycerin transdermal patch. Do not apply the patch to your arms below the elbows, to your legs below the knees, or to skin folds. Apply the patch to clean, dry, hairless skin that is not irritated, scarred, burned, broken, or calloused. Choose a different area each day.

You may shower while you are wearing a nitroglycerin transdermal patch.

If a patch loosens or falls off, replace it with a fresh one.

To use nitroglycerin patches, follow the steps below. Different brands of nitroglycerin patches may be applied in slightly different ways, so be sure to follow the directions included with your patches:

  • Wash your hands.
  • Hold the patch so that the plastic backing is facing you.
  • Bend the sides of the patch away from you and then toward you until you hear a snap.
  • Peel off one side of the plastic backing.
  • Use the other side of the patch as a handle, and apply the stick half to your skin in the spot you have chosen.
  • Press the sticky side of the nitroglycerin transdermal patch against the skin and smooth it down.
  • Fold back the other side of the patch. Hold onto the remaining piece of plastic backing and use it to pull the patch across the skin.
  • Wash your hands again.
  • When you are ready to remove the patch, press down on its center to lift the edges away from the skin.
  • Hold the edge gently and slowly peel the patch away from the skin.
  • Fold the patch in half with the sticky side pressed together and dispose of it safely, out of the reach of children and pets. The used patch may still contain active medication that can harm others.
  • Wash the skin that was covered with the patch with soap and water. The skin may be red and may feel warm for a short time. You may apply lotion if the skin is dry, and you should call your doctor if the redness does not go away after a short time.
  • Nitroglycerin transdermal patches may no longer work as well after you have used them for some time. To prevent this, your doctor will probably tell you to wear each patch for only 12 to 14 hours each day so that there is a period of time when you are not exposed to nitroglycerin every day. If your angina attacks happen more often, last longer, or become more severe at any time during your treatment, call your doctor.

Nitroglycerin patches help prevent attacks of angina but do not cure coronary artery disease. Continue to use nitroglycerin patches even if you feel well. Do not stop using nitroglycerin patches without talking to your doctor.


Keep all appointments with your doctor.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription nitroglycerin transdermal patch.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.