Uses
Sacituzumab govitecan-hziy injection is used to treat a certain type of breast cancer in adults that has spread to other parts of the body and has already been treated with at least two other chemotherapy medications. Sacituzumab govitecan-hziy is in a class of medications called antibody-drug conjugates. It works by killing cancer cells.
Side Effects Of Sacituzumab Govitecan-Hziy
Sacituzumab govitecan-hziy may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- constipation
- mouth sores
- stomach pain
- tiredness
- loss of appetite
- taste changes
- hair loss
- dry skin
- headache
- pain, burning or tingling in the hands or feet
- back pain or joint pain
- pain in arms or legs
- swelling of the hands, ankles, or feet
- difficulty falling asleep or staying asleep
- pale skin or unusual tiredness or weakness
Some side effects can be serious. If you experience any of these symptoms or those listed in the WARNINGS and PRECAUTIONS, call your doctor immediately or get emergency medical treatment:
- easy bruising or bleeding; bleeding from gums or nose; or blood in urine or stool
- Sacituzumab govitecan-hziy may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
Warnings & Precautions
Before receiving sacituzumab govitecan-hziy:
- tell your doctor and pharmacist if you are allergic to sacituzumab govitecan-hziy, any other medications, or any of the ingredients in sacituzumab govitecan-hziy injection. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Carbatrol, Equetro, Teril, others), atazanavir (Reyataz, in Evotaz), indinavir (Crixivan), irinotecan (Camptosar, Onivyde), phenobarbital, rifampin (Rifadin, in Rifater), and sorafenib (Nexavar). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or if you plan to father a child. You or your partner should not become pregnant while you are receiving sacituzumab govitecan-hziy injection. If you are a woman who is able to become pregnant, you must take a pregnancy test before starting treatment and use effective birth control during your treatment and for 6 months after your final dose. If you are male, you and your female partner should use birth control during your treatment and for 3 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you or your partner becomes pregnant while receiving sacituzumab govitecan-hziy injection, call your doctor. Sacituzumab govitecan-hziy may harm the fetus.
- tell your doctor if you are breastfeeding. You should not breastfeed while you are receiving sacituzumab govitecan-hziy and for 1 month after your final dose.
- you should know that this medication may decrease fertility in women. Talk to your doctor about the risks of receiving sacituzumab govitecan-hziy.
Dosage Of Sacituzumab Govitecan-Hziy
Sacituzumab govitecan-hziy comes as a powder to be mixed with liquid and injected intravenously (into a vein) over 1 to 3 hours by a doctor or nurse in a hospital or medical facility. It is usually given on days 1 and 8 of a 21-day cycle. The cycle may be repeated as recommended by your doctor. The length of your treatment depends on how well your body responds to the medication and any side effects that you experience.
Sacituzumab govitecan-hziy injection may cause nausea, vomiting, and serious allergic reactions, which usually occur during the infusion of the medication or within 24 hours of receiving a dose. You will be given other medications to help prevent and treat reactions. A doctor or nurse will watch you carefully during and for at least 30 minutes after the infusion for any reactions to the medication. If you experience any of the following symptoms, tell your doctor immediately: nausea; vomiting; swelling of your face, lips, tongue, or throat; fever; dizziness; flushing; chills; rash; hives; itching; wheezing; or difficulty breathing.
Your doctor may decrease your dose or temporarily or permanently stop your treatment. This depends on how well the medication works for you and the side effects you experience. Be sure to tell your doctor how you are feeling during your treatment with sacituzumab govitecan-hziy.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Other
Ask your pharmacist any questions you have about sacituzumab govitecan-hziy. Your doctor may order certain lab tests before you begin your treatment to see if you may be more likely to have an increased risk for side effects from sacituzumab govitecan-hziy based on your heredity or genetic make-up.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Source
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.
