Uses
Dasabuvir, ombitasvir, paritaprevir, and ritonavir is used alone or in combination with ribavirin (Copegus, Rebetol, Ribasphere) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus). Dasabuvir is a non-nucleoside NS5B polymerase inhibitor. It works by decreasing the amount of HCV in the body. Ombitasvir is a hepatitis C virus (HCV) NS5A inhibitor. It works by stopping the virus that causes hepatitis C from spreading inside the body. Paritaprevir is a protease inhibitor. It works by decreasing the amount of HCV in the body. Ritonavir is a protease inhibitor. It helps to increase the amount of paritaprevir in the body so that the medication will have a greater effect.
Side Effects Of Dasabuvir, Ombitasvir, Paritaprevir, and Ritonavir
Dasabuvir, ombitasvir, paritaprevir, and ritonavir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- difficulty falling asleep or staying asleep
- cough
- irritability
- headache
- diarrhea
- muscle spasms
Some side effects can be serious. If you experience any of these symptoms or those listed in the WARNINGS AND PRECAUTIONS section, call your doctor immediately:
- rash
- reddening of the skin
- itching
- hives
- fatigue or lack of energy
- weakness
- confusion
Dasabuvir, ombitasvir, paritaprevir, and ritonavir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Warnings & Precautions
Before taking dasabuvir, ombitasvir, paritaprevir, and ritonavir:
- tell your doctor and pharmacist if you are allergic to dasabuvir, ombitasvir, paritaprevir, and ritonavir, any other medications, or any of the ingredients in dasabuvir, ombitasvir, paritaprevir, and ritonavir extended-release tablets. If you have had a serious or life-threatening reaction to ritonavir (rash, blistering, or peeling of the skin), your doctor will probably tell you not to take dasabuvir, ombitasvir, paritaprevir, and ritonavir. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor if you are taking alfuzosin (Uroxatral); apalutamide (Erleada); atorvastatin (Lipitor, in Caduet); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cisapride (Propulsid; no longer available in U.S.); dronedarone (Multaq); efavirenz (Sustiva, in Atripla); ergot-containing medicines such as dihydroergotamine mesylate (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); ethinyl estradiol oral contraceptives such as certain (‘birth control pills’), patches, hormonal vaginal rings, and other ethinyl estradiol products; everolimus (Afinitor, Zortress); gemfibrozil (Lopid); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); midazolam (by mouth); phenytoin (Dilantin, Phenytek); phenobarbital; pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sildenafil (Revatio) for treatment of pulmonary arterial hypertension; simvastatin (Flolipid, Zocor, in Vytorin); sirolimus (Rapamune); St. John’s wort; tacrolimus (Astagraf XL, Envarsus XR, Prograf); or triazolam (Halcion). Also, tell your doctor if you are taking colchicine (Colcrys, Mitigare) and have liver or kidney disease. Your doctor will probably tell you not to take dasabuvir, ombitasvir, paritaprevir, and ritonavir if you are taking one or more of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acetaminophen and hydrocodone (Anexsia, Zyfrel); alprazolam (Xanax); angiotensin receptor blockers (ARBs) such as candesartan (Atacand, in Atacand HCT), losartan (Cozaar, in Hyzaar), or valsartan (Diovan, in Diovan HCT, in Exforge); anticoagulants (‘blood thinners’) such as warfarin (Coumadin, Jantoven); buprenorphine and naloxone (Suboxone, Zubsolv); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), nifedipine (Adalat, Procardia), or verapamil (Calan, Verelan, others); carisoprodol (Soma); cyclobenzaprine (Amrix); cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); elagolix (Orilissa); encorafenib (Braftovi); fostamatinib (Tavalisse); fluticasone (Flonase, Flovent, in Advair); furosemide (Lasix); ibrutinib (Imbruvica); ivosidenib (Tibsovo); ketoconazole; medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), bepridil (no longer available in the U.S.), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), or quinidine (in Nuedexta); metformin (Glucophage, Riomet, others); omeprazole (Prilosec); pravastatin (Pravachol); quetiapine (Seroquel); rilpivirine (Edurant; in Complera, in Odefsey); ritonavir (Norvir, in Kaletra) used in combination with other HIV protease inhibitors such as atazanavir (Reyataz), darunavir (Prezista), and lopinavir (in Kaletra); rosuvastatin (Crestor); salmeterol (Serevent, in Advair); and voriconazole (Vfend). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have any type of liver disease other than hepatitis C. Your doctor may tell you not to take this medication.
- tell your doctor if you have ever had a liver transplant, diabetes, or human immunodeficiency virus (HIV).
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking dasabuvir, ombitasvir, paritaprevir, and ritonavir, call your doctor.
- you should know that dasabuvir, ombitasvir, paritaprevir, and ritonavir may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, injections, and intrauterine devices). Use another form of birth control while you are taking this medication and for 2 weeks after your final dose. Talk to your doctor about types of birth control that will work for you during and after your treatment with dasabuvir, ombitasvir, paritaprevir, and ritonavir.
- remember not to drink alcohol within 4 hours of taking dasabuvir, ombitasvir, paritaprevir, and ritonavir extended-release tablets.
Dosage Of Dasabuvir, Ombitasvir, Paritaprevir, and Ritonavir
The combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir comes as extended-release (long-acting) tablets to take by mouth. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take the tablets at around the same time every day. Do not take more or less of it or take it more often than prescribed by your doctor.
The extended-release tablets come in a package with 28 days of medication. Each daily dose pack contains 3 tablets that each contain a combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir. Take dasabuvir, ombitasvir, paritaprevir, and ritonavir (3 tablets) every morning with food. Follow the instructions on each daily dose pack about how to remove the tablets.
Swallow the extended-release tablets whole; do not split, chew, or crush them.
Continue to take dasabuvir, ombitasvir, paritaprevir, and ritonavir even if you feel well. The length of your treatment (12 to 24 weeks) depends on your condition, how well you respond to the medication, and whether you experience severe side effects. Do not stop taking dasabuvir, ombitasvir, paritaprevir, and ritonavir without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Other
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Source
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.
