The combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir is used alone or in combination with ribavirin (Copegus, Rebetol) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus). Ombitasvir is a hepatitis C virus (HCV) NS5A inhibitor. It works by stopping the virus that causes hepatitis C from spreading inside the body. Paritaprevir is a protease inhibitor. It works by decreasing the amount of HCV in the body. Ritonavir is a protease inhibitor. It helps to increase the amount of paritaprevir in the body so that the medication will have a greater effect. Dasabuvir is a non-nucleoside NS5B polymerase inhibitor. It works by decreasing the amount of HCV in the body. It is not known if they prevent the spread of hepatitis C to other people.
Side Effects Of Ombitasvir, Paritaprevir, Ritonavir, And Dasabuvir
Ombitasvir, paritaprevir, ritonavir, and dasabuvir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- difficulty falling asleep or staying asleep
Some side effects can be serious. If you experience any of these symptoms or those listed in the WARNINGS and PRECAUTIONS section, call your doctor immediately:
- reddening of the skin
Ombitasvir, paritaprevir, ritonavir, and dasabuvir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Warnings & Precautions
Before taking ombitasvir, paritaprevir, ritonavir, and dasabuvir:
- tell your doctor and pharmacist if you are allergic to ombitasvir, paritaprevir, ritonavir, dasabuvir, any other medications, or any of the ingredients in ombitasvir, paritaprevir, ritonavir, and dasabuvir tablets. If you have had a serious or life-threatening reaction to ritonavir (rash, blistering, or peeling of the skin), your doctor will probably tell not to take ombitasvir, paritaprevir, ritonavir, and dasabuvir. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor if you are taking alfuzosin (Uroxatral); atorvastatin (Lipitor, in Caduet); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cisapride (Propulsid; no longer available in U.S.); dronedarone (Multaq); efavirenz (Sustiva, in Atripla); ergot-containing medicines such as dihydroergotamine mesylate (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); ethinyl estradiol oral contraceptives such as certain tablets (‘birth control pills’), patches, hormonal vaginal rings, and other esthinyl estradiol products; everolimus (Afinitor, Zortress); gemfibrozil (Lopid); lovastatin (Altoprev); lurasidone (Latuda); midazolam (by mouth); phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sildenafil (Revatio) for treatment of pulmonary arterial hypertension; simvastatin (Zocor, in Vytorin); sirolimus (Rapamune); St. John’s wort; tacrolimus (Astagraf XL, Envarsus XR, Prograf); or triazolam (Halcion). Also, tell your doctor if you are taking colchicine (Colcrys, Mitigare) and have liver or kidney disease. Your doctor will probably tell you not to take ombitasvir, paritaprevir, ritonavir, and dasabuvir if you are taking one or more of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: alprazolam (Xanax); acetaminophen and hydrocodone (Anexsia, Zyfrel); angiotensin receptor blocker (ARB) such as candesartan (Atacand, in Atacand HCT), losartan (Cozaar, in Hyzaar), and valsartan (Diovan, in Diovan HCT, Exforge); buprenorphine and naloxone (Suboxone, Zubsolv); calcium channel blockers such as amlodipine (Norvasc, in Caduet), diltiazem (Cardizem, Cartia), nifedipine (Adalat, Afeditab), and verapamil (Calan, Verelan); carisoprodol (Soma); cyclobenzaprine (Amrix); cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); fluticasone (Flonase, Flovent, in Advair); furosemide (Lasix); medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), bepridil (no longer available in the U.S.), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), or quinidine (in Nuedexta); ketoconazole; metformin (Glucophage, Riomet); omeprazole (Prilosec); pravastatin (Pravachol); quetiapine (Seroquel); rilpivirine (Edurant; in Complera, in Odefsey); ritonavir (Norvir, in Kaletra) used in combination with other HIV protease inhibitors such as atazanavir (Reyataz), darunavir (Prezista), and lopinavir (in Kaletra); rosuvastatin (Crestor); salmeterol (Serevent, in Advair); and voriconazole (Vfend). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have any type of liver disease other than hepatitis C. Your doctor may tell you not to take it.
- tell your doctor if you have ever had a liver transplant, anemia (a lower than a normal number of red blood cells), or human immunodeficiency virus (HIV).
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking ombitasvir, paritaprevir, ritonavir, and dasabuvir, call your doctor.
- you should know that ombitasvir, paritaprevir, ritonavir, and dasabuvir may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, injections, and intrauterine devices). Use another form of birth control while you are taking ombitasvir, paritaprevir, ritonavir, and dasabuvir and for 2 weeks after your final dose. Talk to your doctor about types of birth control that will work for you during and after your treatment with ombitasvir, paritaprevir, ritonavir, and dasabuvir.
Dosage Of Ombitasvir, Paritaprevir, Ritonavir, And Dasabuvir
The combination comes as tablets to take by mouth. This medication comes in a package with 28 days of medication. Each daily dose package has different types of tablets, two containing the combination of ombitasvir, paritaprevir, and ritonavir and two others containing dasabuvir. Take ombitasvir, paritaprevir, and ritonavir (2 tablets), and dasabuvir (1 tablet) every morning with food, then take dasabuvir (1 tablet) every evening with food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ombitasvir, paritaprevir, ritonavir, and dasabuvir at around the same time(s) every day. Do not take more or less of it or take it more often than prescribed by your doctor.
The combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir controls HCV but does not cure it. Continue to take ombitasvir, paritaprevir, ritonavir, and dasabuvir even if you feel well. The length of your treatment (12 to 24 weeks) depends on your condition, how well you respond to the medication, and whether you experience severe side effects. Do not stop taking it without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.