Uses
Irinotecan lipid complex injection is used in combination with other medications to treat pancreatic cancer that has spread to other parts of the body that has worsened after treatment with other chemotherapy medications. Irinotecan lipid complex is in a class of antineoplastic medications called topoisomerase I inhibitors. It works by stopping the growth of cancer cells.
Side Effects Of Irinotecan Lipid Complex Injection
Irinotecan lipid complex may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- unusual tiredness or weakness
- decreased appetite
- nausea
- swelling or sores in the mouth
- hair loss
Some side effects can be serious. If you experience any of these symptoms or those listed in the WARNING section, call your doctor immediately or get emergency medical treatment:
- rash
- itching
- hives
- chest tightness or pain
- wheezing
- new or worsening cough
- swelling of the face, throat, tongue, lips, or eyes
- difficulty breathing or swallowing
- area of red, warm, painful, or swollen skin near the place where the medication was injected
- vomiting
- decreased urination
- swelling in legs and feet
- dizziness
- shortness of breath
- unusual bleeding or bruising
Irinotecan lipid complex may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Warnings & Precautions
Before taking irinotecan lipid complex:
- tell your doctor and pharmacist if you are allergic to irinotecan, any other medications, or any of the ingredients in the irinotecan lipid complex injection. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking carbamazepine (Carbatrol, Equetro, Tegretol, Teril, Epitol), phenobarbital, phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifamate, Rifater), and rifapentine (Priftin). Your doctor will probably tell you not to take these medications for at least 2 weeks before and during your treatment with irinotecan lipid complex.tell your doctor if you are taking clarithromycin (Biaxin, in Prevpac), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole, lopinavir (in Kaletra), nefazodone, nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, Viekira Pak), saquinavir (Invirase), telaprevir (Incivek), and voriconazole (Vfend). Your doctor will probably tell you not to take these medications for at least one week before, and during your treatment with irinotecan lipid complex.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, you are taking or plan to take. Be sure to mention the medications listed above and any of the following: atazanavir (Reyataz, in Evotaz) and gemfibrozil (Lopid). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with irinotecan lipid complex, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on these lists.
- tell your doctor what herbal products you are taking, especially St. John’s wort. Your doctor will probably tell you not to take St. John’s wort for at least 2 weeks before, and during your treatment with irinotecan lipid complex.
- tell your doctor if you have or have ever had liver or kidney disease.
- tell your doctor if you are pregnant or plan to become pregnant, or plan to father a child. You should not become pregnant while you are receiving irinotecan lipid complex and for 1 month after you receive your final treatment. Use a reliable method of birth control during your treatment and for 1 month after your final treatment. If you are a male and your partner can become pregnant, you should use birth control while receiving this medication, and for 4 months after your final treatment. Talk to your doctor about birth control methods that will work for you. If you or your partner become pregnant while receiving irinotecan lipid complex, call your doctor immediately. Irinotecan lipid complex may harm the fetus.
- tell your doctor if you are breast-feeding. Your doctor may tell you not to breast-feed during your treatment and for 1 month after your last treatment.
Dosage Of Irinotecan Lipid Complex Injection
Irinotecan lipid complex comes as a liquid to be injected intravenously (into a vein) over 90 minutes by a doctor or nurse in a medical facility. It is usually given once every 2 weeks.
Your doctor may need to delay your treatment and adjust your dose if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with irinotecan lipid complex.
Your doctor may give you medications to prevent nausea and vomiting before you receive each dose of irinotecan lipid complex. Your doctor may also give you or tell you to take other medication(s) to prevent or treat other side effects.
Other
Keep all appointments with your doctor and the laboratory.
Ask your pharmacist any questions you have about irinotecan lipid complex.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Source
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.
