Vincristine lipid complex is used to treat a certain type of acute lymphoblastic leukemia (ALL; a type of cancer of the white blood cells) that has not improved or that has worsened after at least two different treatments with other medications. Vincristine lipid complex is in a class of medications called vinca alkaloids. It works by slowing or stopping the growth of cancer cells in your body.
Side Effects Of Vincristine Lipid Complex Injection
Vincristine lipid complex may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- loss of appetite
- stomach pain
- trouble falling asleep or staying asleep
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
- pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected
- fever, sore throat, ongoing cough, and congestion, or other signs of infection
- unusual bleeding or bruising
- bloody or black, tarry stools
- unusual tiredness or weakness
- pale skin
- fast heartbeat
- pain, burning, tingling, weakness in the hands or feet
- difficulty walking
- increased or decreased feeling or sensitivity to touch
- decreased or absent reflexes
- muscle or joint pain
- jaw pain
- sudden changes in vision
- sudden decrease or loss of hearing
- confusion or memory loss
- sudden weakness on one side of the face
- Vincristine may increase the risk that you will develop other cancers. Talk to your doctor about the risks of receiving vincristine lipid complex.
Vincristine lipid injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Warnings & Precautions
Before receiving vincristine lipid complex:
- tell your doctor and pharmacist if you are allergic to vincristine, any other medications, or any of the ingredients in vincristine lipid complex injection. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: aprepitant (Emend); carbamazepine (Tegretol); certain antifungals such as itraconazole (Sporanox), ketoconazole (Nizoral), voriconazole (Vfend), and posaconazole (Noxafil); clarithromycin (Biaxin, in Prevpac); dexamethasone (Decadron); HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); nefazodone; phenobarbital; phenytoin (Dilantin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); rifapentine (Priftin); or telithromycin (Ketek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially St. John’s wort.
- tell your doctor if you have or have ever had a disorder that affects your nerves. Your doctor may not want you to receive vincristine lipid complex or may need to change your dose of vincristine lipid complex injection.
- you should know that vincristine may interfere with the normal menstrual cycle (period) in women and may temporarily or permanently stop sperm production in men. Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not become pregnant or breastfeed while you are receiving vincristine lipid complex. If you become pregnant while receiving vincristine lipid complex, call your doctor. Vincristine may harm the fetus.
Vincristine Lipid Complex Dosage
Vincristine lipid complex comes as a liquid to be injected intravenously (into a vein) over 1 hour by a doctor or nurse in a medical facility. It is usually given once every 7 days. The length of treatment depends on the types of drugs you are taking, how well your body responds to them.
Your doctor may need to delay your treatment or change your dose if you experience certain side effects. It is important for you to tell your doctor how you are feeling during your treatment with vincristine lipid complex.
Your doctor may tell you to take a stool softener or laxative to help prevent constipation during your treatment with vincristine lipid complex.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body’s response to vincristine lipid complex.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.