Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate. The effectiveness ratings for LIPASE are as follows:

Insufficient evidence to rate effectiveness for…

  • Indigestion (dyspepsia). Some early evidence shows that taking lipase does not reduce stomach discomfort in people who have indigestion after eating a meal high in fat.
  • Growth and development in premature infants. Human breast milk contains lipase. But donated breast milk and infant formula do not. Early research shows that adding lipase to these products does not help most premature infants grow faster. It might help to increase growth in the smallest infants. But side effects such as gas, colic, stomach pain, and bleeding might also be increased.
  • Celiac disease.
  • Crohn disease.
  • Heartburn.
  • Cystic fibrosis.
  • Other conditions.

More evidence is needed to rate the effectiveness for these uses.

Side Effects Of Lipase

When taken by mouth: There isn’t enough reliable information to know if lipase is safe or what the side effects might be.

Warnings & Precautions

  • Pregnancy and breast-feeding: There isn’t enough reliable information to know if lipase is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
  • Children: A specific form of lipase, called bile salt-stimulated lipase, is POSSIBLY UNSAFE in premature infants when added to the formula. It might increase side effects in the gut. There isn’t enough reliable information to know if other forms are safe in infants or children or what the side effects might be.

Lipase Dosage

The appropriate dose depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for lipase. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


Consult your doctor or pharmacist.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.