Exenatide Injection


Exenatide injection is used along with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Exenatide is in a class of medications called incretin mimetics. It works by stimulating the pancreas to secrete insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Exenatide also slows the emptying of the stomach and causes a decrease in appetite. Exenatide is not used to treat type 1 diabetes (a condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). Exenatide is not used instead of insulin to treat people with diabetes who need insulin.

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

Side Effects Of Exenatide Injection

This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

Exenatide injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • diarrhea
  • constipation
  • jittery feeling
  • dizziness
  • heartburn
  • headache
  • weakness
  • sweating

Some side effects can be serious. If you experience any of the following symptoms or those listed in the WARNINGS section, stop using exenatide and call your doctor immediately or get emergency medical treatment: :

  • ongoing pain that begins in the upper left or middle of the stomach but may spread to the back with or without vomiting
  • hives
  • rash
  • itching
  • difficulty breathing or swallowing
  • injection-site pain, swelling, blisters, itching, or nodules
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • pain in the right or upper middle stomach area, nausea, vomiting, fever, or yellowing of skin or eyes
  • changes in the color or amount of urine
  • urinating more or less often than usual
  • swelling of the arms, hands, feet, ankles, or lower legs
  • decreased appetite

Exenatide may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

Warnings & Precautions

Before using exenatide injection:

  • tell your doctor and pharmacist if you are allergic to exenatide, any other medications, or any of the ingredients in exenatide injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. It is especially important to tell your doctor about all the medications you take by mouth because exenatide may change the way your body absorbs these medications. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavika); diuretics (‘water pills’); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); lovastatin (Altoprev, in Advicor); medications for high blood pressure ; insulin or other medications to treat diabetes such as sulfonylureas such as chlorpropamide (Diabinese), glimepiride (Amaryl, in Avandaryl, in Duetact), glipizide (Glucotrol), glyburide (DiaBeta, in Glucovance), tolazamide, and tolbutamide, and warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • if you are taking oral contraceptives (birth control pills) or antibiotics, take them at least 1 hour before you use exenatide injection. If you have been told to take these medications with food, take them with a meal or snack at a time when you do not use exenatide.
  • tell your doctor if you drink or have ever drunk large amounts of alcohol, and if you are experiencing nausea, vomiting, and diarrhea or think you may be dehydrated, or if you develop these symptoms at any time during your treatment. Also tell your doctor if you have ever had a kidney transplant or if you have or have ever had severe stomach problems, including gastroparesis (slowed movement of food from the stomach to the small intestine) or other problems digesting food; pancreatitis (swelling of the pancreas), gallstones (solid deposits that form in the gallbladder), or a high level of triglycerides (fats) in the blood, or pancreas, liver, or kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using exenatide, call your doctor.
  • ask your doctor about the safe use of alcoholic beverages while you are taking exenatide.
  • ask your doctor what to do if you get sick, develop an infection or fever, experience unusual stress, or are injured. These conditions can affect your blood sugar and the amount of exenatide you may need.

Dosage Of Exenatide Injection

Exenatide immediate-release (Byetta®) comes as a solution (liquid) in a prefilled dosing pen to inject subcutaneously (under the skin). Exenatide extended-release (long-acting) (Bydureon®) comes as a powder to be mixed with the liquid in a vial or a prefilled dosing pen to inject subcutaneously. Exenatide immediate-release solution is usually injected twice a day within 60 minutes before the morning and evening meals; do not inject it after meals. Your doctor will probably start you on a low dose of exenatide immediate-release injection and may switch you to a pen with a higher dose of medication if your blood sugar control has not improved after you have used exenatide for 1 month. Exenatide extended-release solution is injected once weekly at any time of day without regard to meals. Use exenatide extended-release on the same day each week at any time of day. You may change the day of the week that you use exenatide extended-release if it has been 3 or more days since you used your last dose. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use exenatide injection exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

If you are changing from exenatide immediate-release to exenatide extended-release, your glucose (sugar) levels may temporarily increase for 2 to 4 weeks after this change.

Exenatide controls diabetes but does not cure it. Continue to use exenatide even if you feel well. Do not stop using exenatide without talking to your doctor.

If you are using exenatide immediate-release (Byetta®) prefilled dosing pens, you will need to buy needles separately. Ask your doctor or pharmacist what type of needles you will need to inject your medication. Be sure to read and understand the manufacturer’s instructions for injecting exenatide using the pen. Also, make sure you know how and when to set up a new pen. Ask your doctor or pharmacist to show you how to use the pen. Follow the directions carefully. Never remove the cartridge from the pen or attempt to add any other type of medication to the cartridge.

Always look at your exenatide solution before you inject it. It should be as clear, colorless, and fluid as water. Do not use exenatide if it is colored, cloudy, thickened, or contains solid particles, or if the expiration date on the bottle has passed. Do not mix exenatide with insulin into a single injection.

Never reuse needles and never share needles or pens. Always remove the needle right after you inject your dose. Dispose of needles in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture-resistant container.

Exenatide can be administered in the thigh (upper leg), abdomen (stomach), or upper arm. Use a different site for each injection, about 1 inch (2.5 centimeters) away from the previous injection but in the same general area (for example, the thigh). Use all available sites in the same general area before switching to a different area (for example, the upper arm). Do not use the same injection site more often than once every month.

You can inject extended-release exentadine and insulin in the same general area of the body, but the injections should not be given right next to each other.


Your blood sugar and glycosylated hemoglobin (HbA1c) should be checked regularly to determine your response to exenatide. Your doctor will also tell you how to check your response to this medication by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.