TRINTELLIX is a prescription medicine used to treat a certain type of depression called Major Depressive Disorder (MDD). It is important to talk with your healthcare provider about the risks of treating depression and also the risk of not treating it. You should discuss all treatment choices with your healthcare provider.

Side Effects Of Trintellix

TRINTELLIX and other antidepressant medicines may cause serious side effects.

1. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment.

2. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. Some people may have a particularly high risk of having suicidal thoughts or actions. These include people who have (or have a family history of) bipolar illness (also called manic-depressive illness) or suicidal thoughts or actions.

3. How can I watch for and try to prevent suicidal thoughts and actions?

    • Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.
    • Call your healthcare provider right away to report new or sudden changes in mood, behavior, thoughts, or feelings
    • Keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you have concerns about symptoms.

Call your healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you:

  • attempts to commit suicide
  • acting on dangerous impulses
  • acting aggressive, being angry or violent
  • thoughts about suicide or dying
  • new or worse depression
  • new or worse anxiety
  • feeling agitated, restless, angry, or irritable
  • trouble sleeping
  • an extreme increase in  activity or talking (mania)
  • other unusual changes in behavior or mood
  • panic attacks
  • new or worse irritability

Warnings & Precautions

Do not take TRINTELLIX if you:

  • are allergic to vortioxetine, or any of the ingredients in TRINTELLIX.
  • take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid.
  • Do not take an MAOI within 21 days of stopping TRINTELLIX.
  • Do not start TRINTELLIX if you stopped taking an MAOI in the last 14 days.

Before taking TRINTELLIX, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems
  • have or had seizures or convulsions
  • have mania or bipolar disorder (manic depression)
  • have low salt (sodium) levels in your blood
  • have or had bleeding problems
  • drink alcohol
  • have any other medical conditions
  • are pregnant or plan to become pregnant. It is not known if TRINTELLIX will harm your unborn baby. Taking TRINTELLIX while pregnant in your third trimester may cause your newborn baby to have withdrawal symptoms that cause a certain type of breathing problem called Persistent Pulmonary Hypertension of the Newborn (PPHN).
  • are breastfeeding or plan to breastfeed. It is not known if TRINTELLIX passes into breast milk. Talk to your healthcare provider about the best way to feed your baby if you take TRINTELLIX.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. TRINTELLIX and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together.

Especially tell your healthcare provider if you take:

  • medicines used to treat migraine headache (e.g., triptans)
  • medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), buspirone, or antipsychotics
  • MAOIs (including linezolid, an antibiotic)
  • Tramadol or fentanyl
  • over-the-counter supplements such as tryptophan or St. John’s Wort
  • nonsteroidal anti-inflammatory drugs (NSAIDs)
  • aspirin
  • warfarin (Coumadin, Jantoven)
  • diuretics
  • rifampin
  • carbamazepine
  • phenytoin
  • quinidine

Ask your healthcare provider if you are not sure if you are taking any of these medicines.

Dosage Of Trintellix

Take TRINTELLIX exactly as your healthcare provider tells you to take it.

  • Take TRINTELLIX at about the same time each day.
  • Your healthcare provider may need to change the dose of TRINTELLIX until it is the right dose for you.
  • Do not start or stop taking TRINTELLIX without talking to your healthcare provider first. Suddenly stopping TRINTELLIX when you take higher doses may cause you to have side effects
    • Headache
    • the sudden outburst of anger
    • Stiff muscles
    • dizziness or feeling lightheaded
    • mood swings
    • runny nose

• TRINTELLIX may be taken with or without food. If you take too much TRINTELLIX, call the Poison Control Center at 1-800-222-1222 or go to the nearest hospital emergency room right away.


Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use TRINTELLIX for a condition for which it was not prescribed. Do not give TRINTELLIX to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about TRINTELLIX that is written for healthcare professionals.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.