Uses of Artemether and Lumefantrine
The combination of artemether and lumefantrine is used to treat certain kinds of malaria infections (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death). Artemether and lumefantrine should not be used to prevent malaria. Artemether and lumefantrine is in a class of medications called antimalarials. It works by killing the organisms that cause malaria.
Side Effects of Artemether and Lumefantrine
Artemether and lumefantrine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- headache
- dizziness
- weakness
- muscle or joint pain
- tiredness
- difficulty falling asleep or staying asleep
- vomiting
- loss of appetite
- fever
- chills
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
- abnormal or fast heartbeat
- fainting
- rash
- hives
- difficulty breathing or swallowing
- swelling of the lips, tongue, face, or throat
- hoarseness
- difficulty speaking
Artemether and lumefantrine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Warnings & Precautions
Before taking artemether and lumefantrine:
- tell your doctor and pharmacist if you are allergic to artemether and lumefantrine, any other medications, or any of the ingredients in artemether and lumefantrine tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking carbamazepine (Carbatrol, Epitol, Tegretol); phenytoin (Dilantin, Phenytek); rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); or St. John’s wort. Your doctor will probably tell you not to take artemether and lumefantrine if you are taking one or more of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants including amitriptyline (Elavil), clomipramine (Anafranil), and imipramine (Tofranil); certain antifungals such as fluconazole (Diflucan); itraconazole (Sporanox) and ketoconazole (Nizoral); antimalarials such as mefloquine (Lariam) and quinine (Qualaquin); cisapride (Propulsid) (not available in the U.S.); fluoroquinolone antibiotics such as ciprofloxacin (Cipro), gatifloxacin (Tequin) (not available in the U.S.), gemifloxacin (Factive), levofloxacin (Levaquin), lomefloxacin (Maxaquin) (not available in the U.S.), moxifloxacin (Avelox), nalidixic acid (NegGram), norfloxacin (Noroxin), ofloxacin (Floxin), and sparfloxacin (Zagam) (not available in the U.S.); macrolide antibiotics such as clarithromycin (Biaxin, in PrevPac), erythromycin (E.E.S., Ery-tab, Eryc), and telithromycin (Ketek); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva, in Atripla), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), nevirapine (Viramune), rilpivirine (Edurant, in Complera), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), and tipranavir (Aptivus); medications for irregular heartbeat including amiodarone (Cordarone), disopyramide (Norpace), flecainide (Tambocor), procainamide (Procanbid), quinidine, and sotalol (Betapace, Betapace AF, Sorine); and certain medications for mental illness such as pimozide (Orap) and ziprasidone (Geodon). Also, tell your doctor or pharmacist if you are taking or have stopped taking halofantrine (Halfan) (not available in the U.S.) within the past month. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with artemether and lumefantrine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you or anyone in your family has had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death); or if you have or have ever had a slow, fast, or irregular heartbeat; a recent heart attack; a low level of magnesium or potassium in your blood; kidney, heart, or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking artemether and lumefantrine, call your doctor.
- you should know that artemether and lumefantrine may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, and injections). Talk to your doctor about methods of birth control that will work for you while you are taking artemether and lumefantrine.
Dosage
The combination of artemether and lumefantrine comes as a tablet to take by mouth. It is usually taken twice a day for 3 days as instructed by your doctor. Always take artemether and lumefantrine with food. If you are not able to eat, contact your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take artemether and lumefantrine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you have trouble swallowing the tablets, they may be crushed and mixed with 1 or 2 teaspoons of water in a clean container. Drink the mixture right away. Rinse the glass with more water and swallow the entire contents.
You may vomit soon after you take the medication. If you vomit within 1 to 2 hours after you take artemether and lumefantrine, you should take another full dose of artemether and lumefantrine. If you vomit again after taking the extra dose, call your doctor.
You should begin to feel better during the first few days of treatment with artemether and lumefantrine. If your symptoms do not improve or get worse, call your doctor. Also call your doctor if you have a fever, chills, muscle pain, or headache soon after you finish your treatment. This could be a sign that you still are infected with malaria.
Take artemether and lumefantrine until you finish the prescription, even if you feel better. If you stop taking artemether and lumefantrine too soon or skip doses, your infection may not be completely treated and the organisms may become resistant to antimalarials.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Other
Keep all appointments with your doctor.
Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the artemether and lumefantrine, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Source
All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.
