Etidronate is used to treat Paget’s disease of bone (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken) and to prevent and treat heterotopic ossification (growth of bone tissue in an area of the body other than the skeleton) in people who have had total hip replacement surgery (surgery to replace the hip joint with an artificial joint) or in people who have had an injury to the spinal cord. Etidronate is in a class of medications called bisphosphonates. It works by slowing the breakdown of old bone and the formation of new bone.

Side Effects Of Etidronate

Etidronate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • diarrhea

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

Etidronate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before taking etidronate:

  • tell your doctor and pharmacist if you are allergic to etidronate, any other medications, or any of the ingredients in etidronate tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: angiogenesis inhibitors such as bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), or sunitinib (Sutent); anticoagulants (‘blood thinners’) such as warfarin (Coumadin, Jantoven); cancer chemotherapy; and oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • if you are taking vitamin and mineral supplements such as iron, or if you are taking antacids containing calcium, magnesium, or aluminum (Maalox, Mylanta, Tums, others), take them 2 hours before or 2 hours after you take etidronate.
  • tell your doctor if you have or have ever had problems with your esophagus such as an esophageal stricture (narrowing of the esophagus that causes swallowing difficulties) or achalasia (a disorder that affects the ability of the esophagus to move food toward the stomach), or osteomalacia (softening of bones due to a lack of minerals). Your doctor may tell you not to take etidronate.
  • tell your doctor if you are unable to sit or stand upright and if you have or have ever had anemia (a condition in which the red blood cells do not bring enough oxygen to all the parts of the body); a low level of calcium in your blood; difficulty swallowing, heartburn, ulcers, or other stomach problems; cancer; enterocolitis (swelling in the intestines); any type of infection, especially in your mouth; problems with your mouth, teeth, or gums; any condition that stops your blood from clotting normally; or kidney disease. Your doctor may need to change the dose of your medications or monitor you carefully for side effects.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Also, tell your doctor if you plan to become pregnant at any time in the future because etidronate may remain in your body for years after you stop taking it. Call your doctor if you become pregnant during or after your treatment with etidronate.
  • you should know that etidronate may cause osteonecrosis of the jaw (ONJ, a serious condition of the jaw bone), especially if you have dental surgery or treatment while you are taking the medication. A dentist should examine your teeth and perform any needed treatments, including cleaning or fixing ill-fitted dentures, before you start to take etidronate. Be sure to brush your teeth and clean your mouth properly while you are taking etidronate. Talk to your doctor before having any dental treatments while you are taking this medication.
  • you should know that etidronate may cause severe bone, muscle, or joint pain. You may begin to feel this pain within days, months, or years after you first take etidronate. Although this type of pain may begin after you have taken etidronate for some time, it is important for you and your doctor to realize that it may be caused by etidronate. Call your doctor right away if you experience severe pain at any time during your treatment with etidronate. Your doctor may tell you to stop taking etidronate and your pain may go away after you stop taking the medication.

Etidronate Dosage

  • Etidronate comes as a tablet to take by mouth. It is usually taken once a day on an empty stomach. Treatment for Paget’s disease may be repeated if symptoms come back or worsen after some time has passed. Take etidronate at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take etidronate exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor.
  • Etidronate may not work properly and may damage the esophagus (the tube that connects the mouth and stomach) or cause sores in the mouth if it is not taken according to the following instructions. Tell your doctor if you do not understand, you do not think you will remember, or you are unable to follow these instructions:
  • Swallow the tablets with a full glass (6 to 8 ounces [180 to 240 mL]) of plain water while you are sitting or standing.
  • Sit or stand upright after taking etidronate.
  • Do not eat, drink, or take any other medications (including vitamins or antacids) for 2 hours before and 2 hours after you take etidronate.
  • If you are taking etidronate to treat Paget’s disease of bone or to prevent or treat heterotopic ossification, it may take some time for your condition to improve. Do not stop taking etidronate without talking to your doctor.


Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body’s response to etidronate.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.