Uses of Rifamycin

Rifamycin is used to treat of travelers’ diarrhea caused by certain bacteria. Rifamycin is in a class of medications called antibiotics. It works by stopping the growth of the bacteria that cause diarrhea.

Antibiotics such as rifamycin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Side Effects of Rifamycin

Rifamycin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • constipation
  • headache

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • watery or bloody diarrhea that may occur along with stomach cramps and fever during your treatment or for 2 months afterward

Rifamycin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before taking rifamycin:

  • tell your doctor and pharmacist if you are allergic to rifamycin, rifaximin (Xifaxan), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), rifapentine (Priftin), any other medications, or any of the ingredients in rifamycin tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had other medical conditions.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking rifamycin, call your doctor.


Rifamycin comes as a delayed-release (releases the medication in the intestine to allow the medication to work in the intestine where its effects are needed) tablet to take by mouth. It is usually taken twice daily (in morning and evening) with or without food for 3 days. Take rifamycin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take rifamycin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Take each dose with a glass of liquid (at least 6–8 ounces [177–240 milliliters]); do not take it along with alcohol.

Swallow the tablets whole; do not split, chew, or crush them.

You should begin to feel better during the first few days of treatment with rifamycin. If your symptoms do not improve within 48 hours or get worse or if you develop a fever or bloody diarrhea, call your doctor right away.

Take rifamycin until you finish the prescription, even if you feel better. If you stop taking rifamycin too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.


Keep all appointments with your doctor.

Do not let anyone else take your medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.