Teniposide Injection


Teniposide is used with other chemotherapy drugs to treat acute lymphocytic leukemia (ALL; a type of cancer of the white blood cells) in children that has not improved or that has worsened after treatment with other medications. Teniposide is in a class of medications known as podophyllotoxin derivatives. It works by slowing or stopping the growth of cancer cells in your body.

Side Effects Of Teniposide

Teniposide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

Some side effects can be serious. If you experience any of these symptoms or those listed in the WARNINGS and PRECAUTIONS section, call your doctor immediately:

  • blurred vision
  • pale skin
  • excessive tiredness
  • headache
  • confusion
  • pain, numbness, burning or tingling in the hands or feet
  • slow or irregular heartbeat
  • Teniposide may increase the risk that you will develop other cancers. Talk to your doctor about the risks of receiving a teniposide injection.

Teniposide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before receiving teniposide:

  • tell your doctor and pharmacist if you are allergic to teniposide, any other medications, polyoxyethylated castor oil (Cremophor EL), or any of the ingredients in teniposide injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: medications for nausea and vomiting, methotrexate (Abitrexate, Folex, Rheumatrex, Trexall), or tolbutamide (Orinase). Other medications may also interact with teniposide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • tell your doctor if you have or have ever had kidney or liver disease or if you have Down syndrome (an inherited condition causing a range of developmental and physical problems).
  • tell your doctor if you are pregnant, plan to become pregnant, if you are breast-feeding, or if you plan to father a child. You should know that teniposide may stop sperm production in men. You should not become pregnant or breast-feed while you are receiving teniposide injection. If you or your partner become pregnant while receiving teniposide injection, call your doctor. Teniposide may harm the fetus.

Dosage Of Teniposide

Teniposide comes as a solution (liquid) to be injected over at least 30 to 60 minutes intravenously (into a vein) by a doctor or nurse in a medical facility. Your doctor will tell you how often you will receive teniposide. The schedule depends on how your body responds to the medication.


Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body’s response to teniposide.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.