Ifosfamide Injection


Ifosfamide is used in combination with other medications to treat cancer of the testicles that have not improved or that have worsened after treatment with other medications or radiation therapy. Ifosfamide is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.

Side Effects Of Ifosfamide Injection

Ifosfamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • loss of appetite
  • diarrhea
  • sores in the mouth and throat
  • hair loss
  • a general feeling of pain and tiredness

Some side effects can be serious. If you experience any of these symptoms or those listed in the WARNING section, call your doctor immediately:

  • swelling, redness, and pain in the place where the medication was injected
  • rash
  • itching
  • difficulty breathing or swallowing
  • shortness of breath
  • wheezing
  • irregular heartbeat
  • chest pain
  • hoarseness
  • yellowing of the skin or eyes
  • Ifosfamide may increase the risk that you will develop other cancers. Talk to your doctor about the risks of receiving ifosfamide injection.
  • Ifosfamide may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

Warnings & Precautions

Before receiving ifosfamide:

  • tell your doctor and pharmacist if you are allergic to ifosfamide, cyclophosphamide (Cytoxan), any other medications, or any of the ingredients in ifosfamide injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are receiving or plan to take. Be sure to mention the medication listed in the IMPORTANT WARNING section and any of the following: aprepitant (Emend); certain antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); certain seizure medications such as carbamazepine (Tegretrol), phenobarbital (Luminal), and phenytoin (Dilantin); medications for allergies or hay fever; medications for nausea; opioid (narcotic) medications for pain; rifampin (Rifadin, Rimactane); sedatives; sleeping pills; or sorafenib (Nexavar). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Other medications may also interact with ifosfamide, so be sure to tell your doctor about all the medications you are receiving, even those that do not appear on this list.
  • tell your doctor what herbal products you are receiving, especially St. John’s wort.
  • tell your doctor if you have previously received treatment with other chemotherapy medications or if you have previously received radiation therapy. Also tell your doctor if you have or have ever had heart, kidney, or liver disease.
  • you should know that ifosfamide may slow the healing of wounds.
  • you should know that ifosfamide may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. Ifosfamide may cause permanent infertility (difficulty becoming pregnant); however, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. Women who are pregnant or breast-feeding should tell their doctors before they begin receiving this drug. You should not become pregnant or breast-feed while you are receiving ifosfamide. Use a reliable method of birth control to prevent pregnancy while you are receiving ifosfamide and for 6 months after treatments. If you are male, you and your female partner should continue to use birth control for 6 months after you stop receiving ifosfamide injection. If you become pregnant while receiving ifsofamide, call your doctor immediately. Ifosfamide may harm the fetus.

Dosage Of Ifosfamide Injection

Ifosfamide comes as a powder to be mixed with liquid to be injected over at least 30 minutes intravenously (into a vein) by a doctor or nurse in a medical facility. It may be injected once a day for 5 days in a row. This treatment may be repeated every 3 weeks. The length of treatment depends on how well your body responds to treatment with ifosfamide.

Your doctor may need to delay your treatment if you experience certain side effects. It is important for you to tell your doctor how you are feeling during your treatment with ifosfamide.


It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.