OBREDON is a prescription medicine used in adults to treat a cough and to loosen mucus that you can have with a common cold. OBREDON contains 2 medicines, hydrocodone, and guaifenesin. Hydrocodone is an opioid (narcotic) cough suppressant. Guaifenesin is an expectorant.

OBREDON is a federal controlled substance (C-II) because it contains hydrocodone that can be abused or lead to dependence. Keep OBREDON in a safe place to prevent misuse and abuse. Selling or giving away OBREDON may harm others, and is against the law. Tell your healthcare provider if you have abused or been dependent on alcohol, prescription medicines, or street drugs.

Side Effects Of Obredon

OBREDON can cause serious side effects, including:

  • Addiction, abuse, and misuse. Taking OBREDON or other medicines that contain an opioid can cause addiction, abuse, and misuse, which can lead to overdose and death. This can happen even if you take it exactly as prescribed by your healthcare provider. Your risk of addiction, abuse, and misuse is increased if you or a family member has a history of drug or alcohol abuse or addiction or mental health problems.
    • Do not share your OBREDON with other people.
    • Keep OBREDON in a safe place away from children.
  • Life-threatening breathing problems (respiratory depression). OBREDON can cause breathing problems (respiratory depression) that can happen at any time during treatment and can lead to death. Your risk of breathing problems is greatest when you first start taking OBREDON, are taking other medicines that can cause breathing problems, have certain lung problems, are elderly, or have certain other health problems. Children are at higher risk for respiratory depression. Breathing problems can happen even if you take it exactly as prescribed by your healthcare provider.
  • Call your healthcare provider or get emergency medical help right away if anyone taking OBREDON has any of the symptoms below:
      • increased sleepiness
      • confusion
      • difficulty breathing
      • shallow breathing
      • limpness

Keep OBREDON in a safe place away from children. Accidental use of even 1 dose of OBREDON, especially by a child, is a medical emergency and can cause breathing problems (respiratory depression) which can lead to death. If a child accidentally takes OBREDON, get emergency medical help right away.

  • Overdose and death due to medicine dosing errors. Overdose and death can happen if you measure the wrong dose of OBREDON. Always use an accurate milliliter (mL) measuring device to measure the correct amount of OBREDON. Do not use a household teaspoon to measure your medicine. You may accidentally take too much.

You can ask your pharmacist for the measuring device you should use and how to measure the correct dose.

  • Breathing problems (respiratory depression) that can lead to death and opioid withdrawal can happen if you start taking or stop taking other medicines while taking OBREDON, including:

Tell your healthcare provider if you take any of these medicines. Ask your healthcare provider or pharmacist if you are not sure if your medicine is listed above.

  • Severe drowsiness, breathing problems (respiratory depression), coma and death can happen in people who take OBREDON with benzodiazepines or other central nervous system depressants, including alcohol.
    • Do not take benzodiazepines or any medicine that can cause drowsiness or sleepiness during treatment with OBREDON.
    • Do not drink alcohol or take prescription or over-the-counter medicines that contain alcohol during treatment with OBREDON.
  • Opioid withdrawal in a newborn. Use of OBREDON during pregnancy can cause withdrawal symptoms in your newborn baby that could be life-threatening if not recognized and treated. You should not take OBREDON if you are pregnant. Tell your healthcare provider right away if you are pregnant or think you may be pregnant.

Warnings & Precautions

Do not take OBREDON if you:

  • have severe breathing problems (respiratory depression) or breathing problems caused by asthma.
  • have a blockage (obstruction) in your bowel such as paralytic ileus.
  • are allergic to hydrocodone, guaifenesin, or any of the ingredients in OBREDON. See the end of this Medication Guide for a complete list of ingredients.

Before you take OBREDON, tell your healthcare provider about all of your medical conditions, including if you:

  • have a drug addiction
  • have lung or breathing problems
  • have a fever and are coughing up mucus
  • have had a recent head injury
  • have had a brain tumor or other brain problem
  • have or have had seizures
  • have pain in your stomach-area (abdomen)
  • have constipation or other bowel problems
  • have bile duct or pancreas problems
  • have prostate problems
  • have problems with your urinary tract or difficulty urinating
  • have kidney or liver problems
  • have adrenal gland problems
  • have low blood pressure
  • plan to have surgery
  • are pregnant or plan to become pregnant.

Dosage Of Obredon

Take OBREDON exactly as your healthcare provider tells you to take it. Do not change your dose without talking to your healthcare provider.

  • Take it by mouth only.
  • Take OBREDON using an accurate milliliter (mL) measuring device. If you do not have one, ask your pharmacist to give you a measuring device to help you measure the correct amount.


Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use OBREDON for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for health professionals.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.