Doxercalciferol is used to treat secondary hyperparathyroidism (a condition in which the body produces too much parathyroid hormone [PTH; a natural substance needed to control the amount of calcium in the blood]) in certain people with chronic kidney disease and in those treated with dialysis (medical treatment to clean the blood when the kidneys are not working properly). Doxercalciferol is in a class of medications called vitamin D analogs. It works by helping the body to use more of the calcium found in foods or supplements and by regulating the body’s production of parathyroid hormone.

Doxercalciferol Side Effects

Doxercalciferol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • heartburn
  • dizziness
  • sleep problems
  • joint pain
  • weight gain

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • feeling tired, difficulty thinking clearly, loss of appetite, nausea, vomiting, constipation, increased thirst, increased urination, or weight loss
  • swelling of the arms, hands, feet, and legs
  • shortness of breath

Doxercalciferol may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before taking doxercalciferol:

  • tell your doctor and pharmacist if you are allergic to doxercalciferol, any other medications, or any of the ingredients in doxercalciferol capsules. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: calcium supplements, cholestyramine (Prevalite), erythromycin (E.E.S., Ery-Tab, PCE, others), ketoconazole, mineral oil (in laxatives), phenobarbital, or other forms of vitamin D. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. You and your caregiver should know that many nonprescription medications are not safe to take with doxercalciferol. Ask your doctor before you take any nonprescription medications while you are taking doxercalciferol.
  • tell your doctor if you are taking antacids containing magnesium (Maalox, Mylanta) and are being treated for dialysis. Your doctor will probably tell you not to take these antacids during your treatment with doxercalciferol.
  • tell your doctor if you have high blood levels of calcium or vitamin D in your body. Your doctor will probably tell you not to take doxercalciferol.
  • tell your doctor if you have high blood levels of phosphorus or if you have or have ever had liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking doxercalciferol, call your doctor.

Dosage Of Doxercalciferol

Doxercalciferol comes as a capsule to take by mouth. For people receiving dialysis treatments, it is usually taken three times weekly at dialysis sessions. For people with chronic kidney disease who are not receiving dialysis treatments, it is usually taken once daily. Take doxercalciferol at around the same time on the appropriate days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take doxercalciferol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may change your dose depending on your body’s response to doxercalciferol.


Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment with doxercalciferol.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.