Pimozide is used to control motor or verbal tics (an uncontrollable need to repeat certain movements or sounds) caused by Tourette’s disorder (a condition characterized by motor or verbal tics). Pimozide should only be used to treat people who cannot take other medications or who have taken other medications without good results. Pimozide should only be used to treat severe tics that stop the person from learning, working, or performing daily activities.

Pimozide is in a class of medications called conventional antipsychotics. It works by decreasing abnormal excitement in the brain.

Side Effects Of Pimozide

Pimozide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • weakness
  • dizziness, feeling unsteady or having trouble keeping your balance
  • dry mouth
  • increased saliva
  • diarrhea
  • constipation
  • unusual hunger or thirst
  • changes in posture
  • nervousness
  • changes in behavior
  • difficulty tasting food
  • sensitivity to light
  • changes in vision
  • decreased sexual ability in men
  • blank facial expression
  • shuffling walk
  • unusual slowed, or uncontrollable movements of any part of the body
  • restlessness
  • speech problems
  • changes in handwriting
  • rash

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

  • fever
  • muscle stiffness
  • falling
  • confusion
  • sweating
  • fast or irregular heartbeat
  • neck cramps
  • tightness in the throat
  • difficulty breathing or swallowing
  • a tongue that sticks out of the mouth
  • fine, worm-like tongue movements
  • uncontrollable, rhythmic face, mouth, or jaw movements
  • At high doses, pimozide has caused tumors in mice. This does not necessarily mean that pimozide will also cause tumors in humans. Talk to your doctor about the risks of taking this medication.
  • Pimozide may cause a life-threatening irregular heartbeat. Some people who took high doses of pimozide to treat conditions other than Tourette’s syndrome died suddenly, possibly due to this type of irregular heartbeat. Your doctor will order an electrocardiogram (a test that records the electrical activity of the heart) before and during your treatment with pimozide to see whether you already have heart problems that could be worsened by pimozide and to see whether pimozide has caused any heart problems. Talk to your doctor about the risks of taking this medication.

Pimozide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before taking pimozide:

  • tell your doctor and pharmacist if you are allergic to pimozide, other medications for mental illness, or any other medications.
  • tell your doctor if you are taking any of the following medications: certain antibiotics including azithromycin (Zithromax, Z-Pak), clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin, Erythrocin), and moxifloxacin (Avelox); antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); arsenic trioxide (Trisenox); dofetilide (Tikosyn); chlorpromazine; dolasetron (Anzemet); droperidol (Inapsine); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), and ritonavir (Norvir, in Kaletra); medications for irregular heartbeat such as amiodarone (Cordarone), disopyramide (Norpace), procainamide, quinidine, and sotalol (Betapace); medications for mental illness and nausea; mefloquine (Lariam); nefazadone; pentamidine (Nebu-Pent); certain selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), and sertraline (Zoloft); tacrolimus (Prograf); thioridazine; zileuton (Zyflo); and ziprasidone (Geodon). Your doctor may tell you not to take pimozide.
  • tell your doctor if you are taking medications that may cause tics, including amphetamines such as amphetamine (Adderall) and dextroamphetamine (Dexadrine, Dextrostat); pemoline (Cylert) (not available in the US); and methylphenidate (Concerta, Ritalin). Your doctor may tell you to stop taking your medication for a while before you start taking pimozide. This will let your doctor see if your tics were caused by the other medication and can be treated by stopping it.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants; cimetidine (Tagamet); diuretics (‘water pills’); medications for anxiety, pain, and seizures; sedatives; sleeping pills; ticlopidine (Ticlid); and tranquilizers. Many other medications may interact with pimozide, so be sure to tell your doctor about all the medications you are taking, even those not listed here or on the lists above. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had long QT syndrome (a condition that increases the risk of developing an irregular heartbeat that may cause loss of consciousness or sudden death); an irregular heartbeat; or low levels of potassium or magnesium in your blood. Also, tell your doctor if you have severe diarrhea before your treatment or at any time during your treatment. Your doctor may tell you not to take pimozide.
  • tell your doctor if you have or have ever had breast cancer; Parkinson’s disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance); glaucoma (a condition in which increased pressure in the eye can lead to a gradual loss of vision); problems with urination; trouble keeping your balance, an abnormal electroencephalogram (EEG; a test that records electrical activity in the brain); seizures; or prostate, liver, or kidney disease. Also, tell your doctor if you have ever had to stop taking medication for mental illness due to severe side effects.
  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking pimozide, call your doctor. Pimozide may cause problems in newborns following delivery if it is taken during the last months of pregnancy.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking pimozide.
  • you should know that pimozide may make you drowsy and may affect your thinking and movements, especially at the beginning of your treatment. Do not drive a car or operate machinery until you know how this medication affects you.
  • you should know that pimozide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
  • ask your doctor about the safe use of alcohol during your treatment with pimozide. Alcohol can make the side effects of pimozide worse.

Dosage Of Pimozide

Pimozide comes as a tablet to take by mouth. It is usually taken once a day at bedtime or two or more times a day. Take pimozide at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pimozide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of pimozide and gradually increase your dose, not more than once every 2 or 3 days. Your doctor may decrease your dose once your condition is controlled. Be sure to tell your doctor how you are feeling during your treatment with pimozide.

Pimozide controls Tourette’s disorder but does not cure it. It may take some time before you feel the full benefit of pimozide. Continue to take pimozide even if you feel well. Do not stop taking pimozide without talking to your doctor. If you suddenly stop taking pimozide, you may experience difficulty controlling your movements. Your doctor will probably decrease your dose gradually.


Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body’s response to pimozide.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.