Ubrogepant is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light). Ubrogepant is in a class of medications called calcitonin gene-related peptide receptor antagonists. It works by blocking the action of a certain natural substance in the body that causes migraine headaches. Ubrogepant does not prevent migraine attacks or reduce the number of headaches you have.

Side Effects Of Ubrogepant

Ubrogepant may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • drowsiness
  • dry mouth

Ubrogepant may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Warnings & Precautions

Before taking ubrogepant:

  • tell your doctor and pharmacist if you are allergic to ubrogepant, any other medications, or any of the ingredients in ubrogepant tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor what other prescription and nonprescription medications you are taking, especially clarithromycin, itraconazole (Onmel, Sporanox, Tolsura), or ketoconazole. Your doctor will probably tell you not to take ubrogepant if you are taking one or more of these medications.
  • tell your doctor what other prescription and nonprescription medications you are taking, especially ciprofloxacin (Cipro), cyclosporine (Gengraf, Neoral, Sandimmune), fluconazole (Diflucan), fluvoxamine (Luvox), or verapamil (Calan, Verelan, in Tarka). Your doctor may tell you not to take a second ubrogepant tablet within 24 hours if you are taking one or more of these medications.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements you are taking or plan to take. Be sure to mention any of the following: carvedilol (Coreg), eltrombopag (Promacta), phenobarbital, phenytoin (Dilantin, Phenytek), quinidine (in Nuedexta), and rifampin (Rifadin, Rimactane, in Rifamate, Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with ubrogepant, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • tell your doctor what herbal products you are taking, especially curcumin and St. John’s wort.
  • tell your doctor if you have or have ever had kidney or liver problems.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking ubrogepant, call your doctor.

Dosage Of Ubrogepant

Ubrogepant comes as a tablet to take by mouth. It is usually taken at the first sign of a migraine headache. If your symptoms improve after you take ubrogepant but return after 2 hours or longer, your doctor may tell you that you may take a second tablet. Talk to your doctor to see if you may take a second dose if needed. Your doctor will tell you the maximum number of tablets you may take in a 24-hour period. Your doctor will also tell you the maximum number of migraine headaches you should treat with ubrogepant tablets in a 30-day period. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ubrogepant exactly as directed. Do not take more or less of it or take it more often than directed by the package label or prescribed by your doctor.

Call your doctor if your headaches do not get better or occur more frequently after taking ubrogepant.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.


Keep all appointments with your doctor.

You should keep a headache diary by writing down when you have headaches and when you take ubrogepant.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.