Esketamine Nasal Spray

Esketamine Nasal Spray
Esketamine Nasal Spray


Esketamine nasal spray is used along with another antidepressant, taken by mouth, to manage treatment-resistant depression (TRD; depression that does not improve with treatment). Esketamine is in a class of medications called NMDA receptor antagonists. It works by changing the activity of certain natural substances in the brain.

Side Effects Of Esketamine Nasal Spray

Esketamine nasal spray may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • frequent, urgent, burning, or painful urination
  • constipation
  • diarrhea
  • dry mouth
  • nausea
  • vomiting
  • difficulty thinking or feeling drunk
  • headache
  • unusual or metallic taste in the mouth
  • nasal discomfort
  • throat irritation
  • increased sweating

Some side effects can be serious. If you experience any of the symptoms listed in the WARNINGS, call your doctor immediately or get emergency medical treatment.

Esketamine nasal spray may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

Warnings & Precautions

Before using esketamine nasal spray:

  • tell your doctor and pharmacist if you are allergic to esketamine, ketamine, any other medications, or any of the ingredients in esketamine nasal spray. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amphetamines, medications for anxiety, armodafinil (Nuvigil), MAO inhibitors such as phenelzine (Nardil), procarbazine (Matulane), tranylcypromine (Parnate), and selegiline (Eldepryl, Emsam, Zelapar); other medications for mental illness, methylphenidate (Aptension, Jornay, Metadate, others), modafanil, opioid (narcotic) medications for pain, medications for seizures, sedatives, sleeping pills, and tranquilizers. Tell your doctor if you have recently taken any of these medications.
  • if you are using a nasal corticosteroid such as ciclesonide (Alvesco, Omnaris, Zetonna) and mometasone (Asmanex) or nasal decongestant such as oxymetazoline (Afrin) and phenylephrine (Neosynephrine), use it at least 1 hour before using esketamine nasal spray.
  • tell your doctor if you have a blood vessel disease in the brain, chest, stomach area, arms, or legs; have arteriovenous malformation (an abnormal connection between your veins and arteries), or have a history of bleeding in your brain. Your doctor will probably tell you not to use esketamine nasal spray.
  • tell your doctor if you have ever had a stroke, heart attack, brain injury, or any condition that causes increased brain pressure. Tell your doctor if you see, feel, or hear things that are not there; or believe in things that are not true. Also, tell your doctor if you have or have ever had heart valve disease, heart failure, hypertension (high blood pressure), a slow or irregular heartbeat, shortness of breath, chest pain, or liver or heart disease.
  • tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while using esketamine nasal spray, call your doctor immediately. Esketamine nasal spray may harm the fetus.
  • tell your doctor if you are breast-feeding. You should not breastfeed while using esketamine nasal spray.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are using esketamine nasal spray.

Esketamine Nasal Spray Dosage

Esketamine comes as a solution (liquid) to spray into the nose. Initially, it is usually sprayed into the nose twice a week during weeks 1–4, once weekly during weeks 5–8, and then once a week or once every 2 weeks during week 9 and beyond. Esketamine must be used in a medical facility.

Do not eat for at least 2 hours or drink liquids for at least 30 minutes before using esketamine nasal spray.

Each nasal spray device provides 2 sprays (one spray for each nostril). Two green dots on the device tells you that the nasal spray is full, one green dot tells you that one spray was used, and no green dots indicate that the full dose of 2 sprays was used.


It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.