Ingenol Mebutate Topical

Ingenol Mebutate Topical
Ingenol Mebutate Topical


Ingenol mebutate topical gel is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). Ingenol mebutate is in a class of medications called cytotoxic agents. It works by killing fast-growing cells such as the abnormal cells associated with actinic keratoses.

Side Effects Of Ingenol Mebutate Topical

Ingenol mebutate topical gel may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • redness, flaking, scaling, crusting, or swelling of the skin
  • pain, itching, or irritation of the treated skin
  • irritation of the nose and throat
  • headache

Some side effects of ingenol mebutate topical can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

Ingenol mebutate gel may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

Warnings & Precautions

Before using ingenol mebutate topical gel:

  • tell your doctor and pharmacist if you are allergic to ingenol mebutate, any other medications, or any of the ingredients in ingenol mebutate gel. Ask your pharmacist or check the manufacturer’s information for the patient for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any other treatments for actinic keratosis.
  • tell your doctor if you have other skin problems, including side effects from other treatments or sunburn, in the area you will be treating. You should not use ingenol mebutate gel until your skin has healed.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using ingenol mebutate gel, call your doctor.

Ingenol Mebutate Topical Dosage

  • Ingenol mebutate topical comes as a 0.015% or 0.05% gel to apply to the skin. When ingenol mebutate gel is used to treat actinic keratosis on the face or scalp, the 0.015% gel is usually applied once a day for 3 days in a row. When ingenol mebutate gel is used to treat actinic keratosis on the trunk (torso), arms, hands, or legs, the 0.05% gel is usually applied once a day for 2 days in a row. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use ingenol mebutate gel exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
  • Ingenol mebutate gel should be used only on the skin. Do not apply ingenol mebutate gel in or near your eyes, mouth, or vagina. If you get ingenol mebutate gel in your eyes, flush them with large amounts of water right away, and get medical care as soon as possible.
  • Do not apply ingenol mebutate gel right after taking a shower or less than 2 hours before bedtime. After applying ingenol mebutate gel, avoid doing activities that cause a lot of sweating for at least 6 hours.

To use ingenol mebutate topical gel, follow these steps:

  • Remove the cap from a new tube of ingenol mebutate gel just before you are ready to use it.
  • Squeeze the gel from the tube onto your fingertip. Use just enough gel to cover the area your doctor has instructed you to treat. One tube contains enough gel to cover a skin area of about 2 inches by 2 inches.
  • Spread the gel evenly over only the skin area you are treating.
  • Wash your hands right away after applying the gel. Be careful not to touch your eyes before you wash your hands. If the area you are treating is on your hands, wash only the fingertip you used to apply the gel.
  • Safely throw away the tube in the household trash after a single-use.
  • Allow the treated area to dry for 15 minutes. Do not wash or touch the treated area for at least 6 hours. Be careful not to get the gel on the skin of another area of your body or to touch another person with the treated area.
  • Do not cover the treated area with bandages or other dressings.
  • After 6 hours, the treated area can be washed with mild soap and water.
  • Ask your pharmacist or doctor for a copy of the manufacturer’s information on ingenol mebutate topical gel for the patient and instructions for use.


Keep all appointments with your doctor.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.