Oritavancin Injection


Oritavancin injection is used to treat skin infections caused by certain types of bacteria.

Oritavancin is in a class of medications called lipoglycopeptide antibiotics. It works by killing bacteria.

Antibiotics such as oritavancin will not work for colds, flu, and other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Side Effects Of Oritavancin Injection

Oritavancin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea
  • nausea
  • vomiting
  • dizziness
  • headache
  • redness and swelling at the infusion site
  • tachycardia

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)
  • swelling of the lips, face, hands, or legs, itching, hives, rash, wheezing
  • signs of new skin infections such as a new painful, red, swollen area on your skin
  • Oritavancin injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

Warnings & Precautions

Before using oritavancin injection:

  • tell your doctor and pharmacist if you are allergic to oritavancin, dalbavancin (Dalvance), telavancin (Vibativ), vancomycin (Vancocin), any other medications, or any of the ingredients in oritavancin injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you are receiving heparin injection. Your doctor will probably stop your heparin for at least 5 days after receiving oritavancin injection.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have any medical conditions.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

Oritavancin Injection Dosage

Oritavancin injection comes as a powder to be mixed with liquid and given through a needle or catheter placed in your vein. It is usually injected slowly over 3 hours as a one-time dose by a doctor or nurse.

You may experience a reaction while you receive a dose of oritavancin. Tell your doctor immediately if you experience any of these symptoms while you receive oritavancin: sudden reddening of the face, neck, upper chest, or other body parts; itching; rash; and hives. Your doctor may slow or stop the infusion until your symptoms improve.

You should begin to feel better after receiving treatment with oritavancin injection. If your symptoms do not improve or get worse, call your doctor.


Keep all appointments with your doctor and the laboratory.

Before having any laboratory test within 5 days of receiving oritavancin, tell your doctor and the laboratory personnel that you have received this medication.

If you still have symptoms of infection after you finish your treatment with oritavancin injection, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.