Myelodysplastic Syndrome (MDS)

Myelodysplastic Syndrome (MDS)
Myelodysplastic Syndrome (MDS)

Overview Of Myelodysplastic Syndrome (MDS)

Myelodysplastic syndrome is a group of disorders when the blood cells produced in the bone marrow do not mature into healthy cells. This leaves you with fewer healthy blood cells in your body. The blood cells that have matured may not function properly.

Myelodysplastic syndrome (MDS) is a form of cancer. In about a third of people, MDS may develop into acute myeloid leukemia.

Commonly Associated With

Myeloid malignancy; Preleukemia; Smoldering leukemia; Refractory anemia; Refractory cytopenia

Causes Of Myelodysplastic Syndrome (MDS)

Stem cells in bone marrow form different types of blood cells. With MDS, the DNA in stem cells becomes damaged. Because the DNA is damaged, the stem cells can’t produce healthy blood cells.

The exact cause of MDS is not known. In most cases, there is no known cause.

Risk factors for MDS include:

  • Certain genetic disorders
  • Exposure to environmental or industrial chemicals, fertilizers, pesticides, solvents, or heavy metals
  • Smoking
  • Prior cancer treatment increases the risk for MDS. This is called secondary or treatment-related MDS.
  • Certain chemotherapy drugs increase the chance of developing MDS. This is a major risk factor.
  • Radiation therapy, when used with chemotherapy, increases the risk for MDS even more.
  • People who have stem cell transplants may develop MDS because they also receive high doses of chemotherapy.
  • MDS usually occurs in adults age 60 years and older. It is more common in men.

Symptoms Of Myelodysplastic Syndrome (MDS)

Early-stage MDS often has no symptoms. MDS is often discovered during other blood tests.

People with very low blood counts often experience symptoms. Symptoms depend on the type of blood cell affected, and they include:

  • Weakness or tiredness due to anemia
  • Shortness of breath
  • Easy bruising and bleeding
  • Small red or purple pinpoint dots under the skin caused by bleeding
  • Frequent infections and fever

Exams & Tests

People with MDS have a shortage of blood cells. MDS may reduce the number of one or more of these:

  • Red blood cells
  • White blood cells
  • Platelets
  • The shapes of these cells may also be changed. Your health care provider will perform a complete blood count and blood smear to find which type of blood cells have been affected.

Other tests that may be performed are:

  • Bone marrow aspiration and biopsy.
  • Cytochemistry, flow cytometry, immunocytochemistry, and immunophenotyping tests are used to identify and classify specific types of MDS.
  • Cytogenetics and fluorescent in situ hybridization (FISH) are used for genetic analysis. Cytogenetic testing can detect translocations and other genetic abnormalities. FISH is used to identify specific changes within chromosomes. Genetic variations may help determine response to treatment.
  • Some of these tests will help your provider determine what type of MDS you have. This will help your provider plan your treatment.

Your provider may define your MDS as high-risk, intermediate-risk, or low-risk on the basis of:

  • The severity of shortage of blood cells in your body
  • The types of changes in your DNA
  • The number of immature white blood cells in your bone marrow
  • Since there is a risk of MDS developing into AML, regular follow-up with your provider may be required.

Treatment Of Myelodysplastic Syndrome (MDS)

Your treatment will depend on several factors:

  • Whether you are low-risk or high-risk
  • The type of MDS you have
  • Your age, health, and other conditions you may have, such as diabetes or heart disease

The goal of MDS treatment is to prevent problems due to a shortage of blood cells, infections, and bleeding. It may consist of:

  • Blood transfusion
  • Drugs that promote the production of blood cells
  • Drugs that suppress the immune system
  • Low-dose chemotherapy to improve blood cell counts
  • Stem cell transplantation
  • Your provider may try one or more treatments to see what your MDS responds to.