Brexanolone Injection


Brexanolone injection is used for the treatment of postpartum depression (PPD) in adults. Brexanolone injection is in a class of medications called neurosteroid antidepressants. It works by changing the activity of certain natural substances in the brain.

Side Effects Of Brexanolone Injection

Brexanolone injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dry mouth
  • heartburn
  • mouth or throat pain
  • flushing
  • hot flashes
  • dizziness or a spinning sensation
  • fatigue

Some side effects can be serious. If you experience any of these symptoms or those listed in the WARNING section, call your doctor immediately or get emergency medical treatment:

  • racing heartbeat

Brexanolone injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

Warnings & Precautions

Before receiving brexanolone injection:

  • tell your doctor and pharmacist if you are allergic to any other medications, or any of the ingredients in brexanolone injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants, benzodiazepines including alprazolam (Xanax), diazepam (Diastat, Valium), midazolam, or triazolam (Halcion); medications for mental illness, medications for pain such as opioids, medications for seizures, sedatives, sleeping pills, and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had kidney disease.
  • tell your doctor if you are pregnant or if you think you may be pregnant, or are breast-feeding.
  • you should know that alcohol can make the side effects from brexanolone injection worse. Do not drink alcohol while receiving brexanolone.
  • you should know that your mental health may change in unexpected ways when you receive brexanolone injection or other antidepressants even if you are an adult over age 24. You may become suicidal, especially at the beginning of your treatment and any time that your dose is changed. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

Brexanolone Injection Dosage

Brexanolone injection comes as a solution to be injected intravenously (into your vein). It is usually given as a one-time infusion over 60 hours (2.5 days) in a medical facility.

Your doctor may temporarily or permanently stop your treatment or adjust your dose of brexanolone depending on your response to treatment and any side effects that you experience.

Brexanolone may be habit-forming. While receiving brexanolone injection, discuss your treatment goals with your healthcare provider.


Ask your pharmacist any questions you have about brexanolone injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.