Duzallo

Uses

DUZALLO is a prescription medicine that contains 2 medicines, a URAT1 inhibitor called lesinurad and a xanthine oxidase inhibitor called allopurinol.

DUZALLO is used to lower uric acid levels in the blood in people with gout when allopurinol alone has not worked well enough. It is not known if it is safe and effective in children under 18 years of age.

Side Effects Of Duzallo

DUZALLO may cause serious side effects including:

• Liver problems. Liver problems can happen in people who take DUZALLO. Call your healthcare provider if you have any of the following symptoms:
• •  loss of appetite
  •  weight loss
  •  feeling very tired
  • nausea or vomiting
  •  yellowing of your skin or the white part of your eyes
  •  itching
  •  dark or brown (tea-colored) urine
  •  pain on the upper right side of your stomach
• Heart problems. People who take DUZALLO can have serious heart problems including heart attack and stroke. It is not known that it causes these problems.
• Blood problems. DUZALLO can affect your bone marrow and cause low red blood cells, white blood cells, and platelets. If your blood cell counts become very low, you can get infections or have bleeding problems. Taking it with certain other medicines can increase your chance of having blood problems.

The most common side effects of DUZALLO include:

• headache
• flu
• higher levels of blood creatinine (a measure of kidney function)
• heartburn (acid reflux)
• skin rash
• nausea
• diarrhea

Tell your healthcare provider if you have any side effect that bothers you, or that does not go away. These are not

all of the possible side effects of DUZALLO. For more information, ask your healthcare provider or pharmacist.

Warnings & Precautions

Do not take DUZALLO if you have:

• severe kidney problems received a kidney transplant or you are on dialysis
• a fast breakdown of cancer cells that can lead to high uric acid (Tumor lysis syndrome)
• a rare inherited condition that causes too much uric acid in the blood (Lesch-Nyhan syndrome)
• had a skin rash or other allergic reaction after taking allopurinol

Before taking DUZALLO, tell your healthcare provider about all of your medical conditions, including if you:

• have kidney or liver problems.
• are pregnant or plan to become pregnant. It is not known if DUZALLO will harm your unborn baby.
• are breastfeeding or plan to breastfeed. Allopurinol can pass into your breast milk.Talk to your healthcare provider about the best way to feed your baby if you take DUZALLO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DUZALLO may affect the way other medicines work, and other medicines may affect how DUZALLO works.

Especially tell your healthcare provider if you take:

• certain medicines that lower your immune system including mercaptopurine and azathioprine
• blood thinner medicines
• medicines for heart conditions or high blood pressure
• medicines for high blood cholesterol
• antifungals and antibiotics
• valproic acid
• aspirin
• other medicines for gout
• hormonal contraceptives. Women who use birth control medicines containing hormones to prevent pregnancy (birth control pills, skin patches, implants, and certain IUDs) should use a back-up method of birth control during treatment with DUZALLO.

Ask your healthcare provider or pharmacist if you are not sure if you take any of these medicines.

Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

Duzallo Dosage

Take DUZALLO exactly as your healthcare provider tells you to take it.

• Take 1 DUZALLO tablet each day in the morning. Do not take more than 1 tablet each day.
• Do not take DUZALLO with ZURAMPIC® (lesinurad).
• Take it with food and water.
• Drink 2 liters (68 ounces) of fluid each day to stay hydrated.
• If you miss a dose of DUZALLO in the morning, do not take DUZALLO later in the day. Wait and take your next dose of 1 tablet the next morning. Do not double your dose of DUZALLO.
• Your gout may get worse (flare-up) when you first start taking it. Do not stop taking DUZALLO even if you have a flare-up. Your healthcare provider may give you other medicines to help prevent your gout flare-ups.

Other

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use DUZALLO for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about DUZALLO that is written for health professionals.

Source

All information has been provided courtesy of MedLinePlus from the National Library of Medicine and from the FDA.